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Viremia control following antiretroviral treatment and therapeutic immunization during primary SIV251 infection of macaques
- Source :
- Nature medicine. 6(10)
- Publication Year :
- 2000
-
Abstract
- Prolonged antiretroviral therapy (ART) is not likely to eradicate human immunodeficiency virus type I (HIV-I) infection. Here we explore the effect of therapeutic immunization in the context of ART during primary infection using the simian immunodeficiency virus (SIV251) macaque model. Vaccination of rhesus macaques with the highly attenuated poxvirus-based NYVAC-SIV vaccine expressing structural genes elicited vigorous virus-specific CD4 + and CD8+ T cell responses in macaques that responded effectively to ART. Following discontinuation of a six-month ART regimen, viral rebound occurred in most animals, but was transient in six of eight vaccinated animals. Viral rebound was also transient in four of seven mock-vaccinated control animals. These data establish the importance of antiretroviral treatment during primary infection and demonstrate that virus-specific immune responses in the infected host can be expanded by therapeutic immunization.
- Subjects :
- CD4-Positive T-Lymphocytes
viruses
Simian Acquired Immunodeficiency Syndrome
Gene Products, gag
Context (language use)
Viremia
CD8-Positive T-Lymphocytes
medicine.disease_cause
Vaccines, Attenuated
Macaque
Antiviral Agents
General Biochemistry, Genetics and Molecular Biology
Immune system
biology.animal
medicine
Animals
Vaccines, Synthetic
biology
business.industry
Poxviridae
Vaccination
General Medicine
Simian immunodeficiency virus
medicine.disease
Virology
Macaca mulatta
Discontinuation
Immunization
Immunology
business
Subjects
Details
- ISSN :
- 10788956
- Volume :
- 6
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Nature medicine
- Accession number :
- edsair.doi.dedup.....998734a746945ecd5ecd21fa37e0a050