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Rapid radiosynthesis of two [ 18 F]‐labeled nicotinamide derivatives for malignant melanoma imaging
- Source :
- Applied Radiation and Isotopes. 132:142-146
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- The rapid synthesis of two radiofluoronicotinamide derivatives, namely, [18F]MEL050 and [18F]MEL-2F has been simply performed starting from commercial materials. [18F]MEL-2F is a new, potential analogue PET-probe for melanoma imaging. [18F]MEL050 is already an excellent PET imaging probe for early specific diagnosis. The synthesis involves coupling step to obtain the precursor followed by radiofluorination. During the synthesis of the precursors different coupling reagents, such as HBTU, TFFH, HOBT, COMU and PyCIU have been applied. PyClU was found the best to reduce the coupling period to
- Subjects :
- Radiation
Nicotinamide
010405 organic chemistry
Chemistry
Melanoma
Radiosynthesis
Orvostudományok
Pet imaging
Klinikai orvostudományok
medicine.disease
01 natural sciences
Combinatorial chemistry
030218 nuclear medicine & medical imaging
0104 chemical sciences
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
Subjects
Details
- ISSN :
- 09698043
- Volume :
- 132
- Database :
- OpenAIRE
- Journal :
- Applied Radiation and Isotopes
- Accession number :
- edsair.doi.dedup.....9986cf73bb5d4f1fcb6112057ff657c9