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Bisphenol A induces ovarian cancer cell proliferation and metastasis through estrogen receptor-α pathways
- Source :
- Environmental Science and Pollution Research. 28:36060-36068
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Bisphenol A (BPA) is a widely used raw material that can be detected both in the environment and in the human body. Due to its estrogen-like effects, wide concerns have been raised about the potential role of BPA in the initiation and development of hormone-dependent cancers. Ovarian cancer is the most common reproductive system cancer and has a high mortality rate in women. Despite recent investigations into BPA's carcinogenic effects, studies on its role in ovarian cancer development remain limited. In this study, we aimed to assess the effect of BPA at various environmentally relevant concentrations on proliferation and metastasis of ovarian cancer cells. We discovered that BPA can stimulate proliferation of OVCAR-3 ovarian cancer cells after exposure for up to 5 days. Strikingly, BPA enhanced ovarian cancer cell migration, invasion, and adhesion (to vascular endothelial cells) through upregulation of matrix metalloproteinase-2 (MMP-2), MMP-9, and intercellular cell adhesion molecule-1 (IMAC-1). The stimulatory effects of BPA on cancer cell proliferation and metastasis were reversed by treatment with an ERα inhibitor, but not by treatment with an ERβ inhibitor. Together, these results suggest that BPA induces proliferation and metastasis of ovarian cancer cells through ERα signaling pathways. This study provides new insights into the carcinogenic effects of BPA with regard to ovarian cancer.
- Subjects :
- endocrine system
Health, Toxicology and Mutagenesis
Estrogen receptor
Apoptosis
010501 environmental sciences
01 natural sciences
Metastasis
Phenols
Cell Line, Tumor
Humans
Environmental Chemistry
Medicine
Benzhydryl Compounds
Cell adhesion
Carcinogen
Cell Proliferation
0105 earth and related environmental sciences
Ovarian Neoplasms
urogenital system
business.industry
Cell growth
Estrogen Receptor alpha
Endothelial Cells
Cancer
Cell migration
General Medicine
medicine.disease
Pollution
Receptors, Estrogen
Cancer research
Matrix Metalloproteinase 2
Female
business
Ovarian cancer
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 16147499 and 09441344
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Environmental Science and Pollution Research
- Accession number :
- edsair.doi.dedup.....9974a8dc111f8d0b9878b0208be29ccb