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Increased lymphocyte infiltration in patients with head and neck cancer treated with the IRX-2 immunotherapy regimen
- Source :
- Cancer Immunology, Immunotherapy. 61:771-782
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- Twenty-seven subjects with squamous cell cancer of the head and neck received the neoadjuvant IRX-2 immunotherapy regimen prior to surgery in a Phase 2 trial. Pretreatment tumor biopsies were compared with the primary tumor surgical specimens for lymphocyte infiltration, necrosis and fibrosis, using hematoxylin and eosin stain and immunohistochemistry in 25 subjects. Sections were examined by three pathologists. Relative to pretreatment biopsies, increases in lymphocyte infiltration (LI) were seen using H and E or immunohistochemistry. CD3+ CD4+ T cells and CD20+ B cells were primarily found in the peritumoral stroma and CD3+ CD8+ T cells and CD68+ macrophages were mainly intratumoral. LI in the surgical specimens were associated with reductions in the primary tumor size. Improved survival at 5 years was correlated with high overall LI in the tumor specimens. Neoadjuvant IRX-2 immunotherapy regimen may restore immune responsiveness presumably by mobilizing tumor infiltrating effector lymphocytes and macrophages into the tumor.
- Subjects :
- Adult
Male
Cancer Research
Pathology
medicine.medical_specialty
medicine.medical_treatment
Immunology
H&E stain
Article
Lymphocytes, Tumor-Infiltrating
Immune system
medicine
Humans
Immunology and Allergy
Aged
CD20
biology
business.industry
CD68
Immunotherapy
Middle Aged
medicine.disease
Survival Analysis
Primary tumor
Oncology
Head and Neck Neoplasms
biology.protein
Cytokines
Regression Analysis
Immunohistochemistry
Female
business
CD8
Subjects
Details
- ISSN :
- 14320851 and 03407004
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Cancer Immunology, Immunotherapy
- Accession number :
- edsair.doi.dedup.....996dd8a7e44868cbd583f46433a9fa2c