The Role of TMEM127 in mTOR Pathway and Cancer Suppression

Transmembrane Protein 127 (TMEM127), also known as FLJ20507, mutated in pheochromocytomas and renal cancers. The current study found that TMEM127 is widely distributed, versatile and closely related to the occurrence of disease. In this article, We summarize the function of TMEM127 in the signaling pathway and its impact on disease in detail. In the mTOR signaling pathway, TMEM127 regulates cell growth and proliferation, and acts as a tumor suppressor to inhibit tumorigenesis. Moreover, it can be used as a diagnostic indicator in pheochromocytoma and hereditary paraganglioma-pheochromocytoma syndrome. In addition, we have integrated the current clinical data and monitoring methods. This will provide ideas for further exploration of the function of TMEM127 and also provide a basis for the diagnosis and treatment of related diseases.Read Complete Article at ijSciences: V82019031985 AND DOI: http://dx.doi.org/10.18483/ijSci.1985