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Electroconvulsive therapy improves clinical manifestations of treatment-resistant depression without changing serum BDNF levels
- Source :
- Psychiatry research. 227(2-3)
- Publication Year :
- 2014
-
Abstract
- Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in serum brain-derived neurotrophic factor (sBDNF) levels and clinical improvement following ECT in patients with TRD. Twenty-one patients with TRD (2 men, 19 women; mean age, 63.5 years; S.D., 11.9) were assessed through the Hamilton Depression Rating Scale (HDRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions scale, Severity (CGIs) before and after a complete ECT cycle. At the same time-points, patients underwent blood withdrawal for measuring sBDNF levels. ECT significantly reduced HDRS, BPRS, and CGIS scores, but not sBDNF levels. No significant correlation was found between sBDNF changes, and each of HDRS, BPRS, and CGIs score changes. sBDNF levels in TRD patients were low both at baseline and post-ECT. Our results do not support that improvements in TRD following ECT are mediated through increases in sBDNF levels.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
behavioral disciplines and activities
Depressive Disorder, Treatment-Resistant
Electroconvulsive therapy
Neurotrophic factors
Rating scale
Internal medicine
mental disorders
Brief Psychiatric Rating Scale
medicine
Major depression
Humans
In patient
brain-derived neurotrophic factor (BDNF)
Psychiatry
Electroconvulsive Therapy
Biological Psychiatry
Depression (differential diagnoses)
Aged
bipolar depression
Brain-Derived Neurotrophic Factor
Mean age
Middle Aged
medicine.disease
serum levels
Psychiatry and Mental health
Treatment Outcome
electroconvulsive therapy (ECT)
Female
brain-derived neurotrophic factor (BDNF), serum levels
Treatment-resistant depression
Psychology
Subjects
Details
- ISSN :
- 18727123
- Volume :
- 227
- Issue :
- 2-3
- Database :
- OpenAIRE
- Journal :
- Psychiatry research
- Accession number :
- edsair.doi.dedup.....99593658183be42fb56c9ac14891d1eb