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Quality of Life in Patients after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Is It Worth the Risk?
- Source :
- Annals of Surgical Oncology. 20:226-232
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- To investigate the course of health-related quality of life (HQL) over time in patients with peritoneal carcinomatosis (PC) after complete cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Prospective, single-center, nonrandomized cohort study using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire. Ninety patients who underwent CRS and HIPEC for PC in our institution were enrolled in the study. Mean age was 56 years (range 27–77 years) (61 % female). Primary tumor was colorectal in 21 %, ovarian in 19 %, pseudomyxoma peritonei in 16 %, an appendix tumor in 16 %, gastric cancer in 10 %, and peritoneal mesothelioma in 13 % of cases. Mean peritoneal carcinomatosis index was 22 (range 2–39). Mean global health status score was 69 ± 25 preoperatively and 55 ± 20, 66 ± 22, 66 ± 23, 71 ± 23, and 78 ± 21 at months 1, 6, 12, 24, and 36, respectively. Physical and role function recovered significantly at 6 months and were close to baseline at the 24-month measurement. Emotional function starting from a low baseline recovered to baseline by month 12. Cognitive and social function had slow recovery on follow-up. Fatigue, diarrhea, dyspnea, and sleep disturbance were symptoms persistent at 6-month follow-up, improving later on in survivors. Survivors after CRS and HIPEC have postoperative quality of life similar to preoperatively, with most of the reduced elements recovering after 6–12 months. We conclude that reduced quality of life of patients after CRS and HIPEC should not be used as an argument to deny surgical therapy to these patients.
- Subjects :
- Adult
Diarrhea
Male
Mesothelioma
medicine.medical_specialty
Time Factors
Antineoplastic Agents
Quality of life
Surgical oncology
Surveys and Questionnaires
medicine
Humans
Pseudomyxoma peritonei
Fatigue
Peritoneal Neoplasms
Aged
Ovarian Neoplasms
business.industry
Carcinoma
Cancer
Hyperthermia, Induced
Middle Aged
Pseudomyxoma Peritonei
medicine.disease
Combined Modality Therapy
Primary tumor
Dyssomnias
Surgery
Dyspnea
Appendiceal Neoplasms
Oncology
Quality of Life
Peritoneal mesothelioma
Female
Hyperthermic intraperitoneal chemotherapy
Colorectal Neoplasms
business
Cohort study
Subjects
Details
- ISSN :
- 15344681 and 10689265
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Annals of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....9957f9d4f0b6cd0903c23f6b5d3541a4