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Review on Retinal Gliosis Illustrated with a Series of Massive Glioses and Focal Nodular Gliosis Cases in Regard to Potential Pitfalls of Ocular Reactive Tumor-like Lesions of this Type
- Source :
- Folia Medica, Vol 60, Iss 1, Pp 30-38 (2018)
- Publication Year :
- 2018
- Publisher :
- Pensoft Publishers, 2018.
-
Abstract
- This paper presents a review on retinal gliosis illustrated by series of three cases of patients (a 39-year-old man and a 35-year-old woman with massive retinal gliosis (MRG) and a 51-year-old man with truly focal nodular gliosis of retina) with intraocular tumor-like masses and loss of vision, who recently suffered from painful inflammation of eyeball and who classically had a history of remote ocular trauma, onset of blindness early in lifetime or gradual but progressive loss of sight. The diagnosis of this pathological entity is given for the lesions that are composed of GFAP strongly positive, elongated, fusiform cells consistent with fibrillary astrocytes. As illustrated in cases from our pathological practice, PAS gave positive patchy disseminated reaction in form of cellular densely purplish granules in minority of cells representing glycogen storing. This feature could be consistent with PAS-positive Müller cells that also constitute retinal gliosis as one of cellular components of normal retina that is induced to reactive proliferation. Thus, the paper presents histological background and differential diagnosis of the entity.
- Subjects :
- 0301 basic medicine
Adult
Male
Pathology
medicine.medical_specialty
reactive changes
fibrillary astrocytes
lcsh:Medicine
Inflammation
Ocular trauma
Retina
Diagnosis, Differential
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Retinal Diseases
Medicine
Humans
Gliosis
Pathological
Müller cells
business.industry
Histocytochemistry
lcsh:R
Retinal
General Medicine
Middle Aged
030104 developmental biology
medicine.anatomical_structure
retinal gliosis
intraocular tumor
chemistry
030220 oncology & carcinogenesis
Female
Differential diagnosis
medicine.symptom
business
Fibrillary astrocytes
Subjects
Details
- Language :
- English
- ISSN :
- 13142143
- Volume :
- 60
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Folia Medica
- Accession number :
- edsair.doi.dedup.....995308698ef9d3dc17a458adf35854db