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Efficacy of Bacteriophages in a Staphylococcus aureus Nondiabetic or Diabetic Foot Infection Murine Model
- Source :
- Antimicrob Agents Chemother
- Publication Year :
- 2019
-
Abstract
- This study investigated the in vivo efficacy of three bacteriophages combined compared with linezolid in two mouse models (nondiabetic and diabetic) of Staphylococcus aureus foot infection. In both models, a single injection of bacteriophages in the hindpaw showed significant antibacterial efficacy. Linezolid was as effective as bacteriophages in nondiabetic animals but ineffective in diabetic animals. These findings further support preclinical and clinical studies for the development of phage therapy.
- Subjects :
- Staphylococcus aureus
Phage therapy
medicine.medical_treatment
medicine.disease_cause
Microbiology
03 medical and health sciences
chemistry.chemical_compound
Mice
In vivo
medicine
Animals
Pharmacology (medical)
Bacteriophages
Experimental Therapeutics
Phage Therapy
Pharmacology
0303 health sciences
Mice, Inbred BALB C
030306 microbiology
business.industry
030302 biochemistry & molecular biology
Linezolid
Single injection
Staphylococcal Infections
medicine.disease
Diabetic foot
Diabetic Foot
Anti-Bacterial Agents
Disease Models, Animal
Infectious Diseases
chemistry
Murine model
Female
business
Foot (unit)
Subjects
Details
- ISSN :
- 10986596
- Volume :
- 64
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Antimicrobial agents and chemotherapy
- Accession number :
- edsair.doi.dedup.....995011cdf8a8c3150de0e9393042234a