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Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels
- Source :
- Brain Research. 1056:97-99
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- By administration of bacterial lipopolysaccharide (LPS) to intact and T4-replaced thyroidectomized rats, we demonstrate that in contrast to the cortex and anterior pituitary, there is a persistent increase in type 2 iodothyronine deiodinase (D2) activity in the mediobasal hypothalamus (MBH). We propose that endotoxin-induced D2 activation in the MBH is independent of circulating levels of thyroid hormone and that this mechanism may contribute to central hypothyroidism associated with infection.
- Subjects :
- Lipopolysaccharides
Male
Thyroid Hormones
endocrine system
Pituitary gland
medicine.medical_specialty
Time Factors
Deiodinase
Hypothalamus, Middle
Biology
Iodide Peroxidase
Body Temperature
Rats, Sprague-Dawley
Anterior pituitary
Internal medicine
medicine
Animals
Molecular Biology
General Neuroscience
Thyroid
Rats
Enzyme Activation
medicine.anatomical_structure
Endocrinology
Hypothalamus
Iodothyronine deiodinase
Thyroidectomy
biology.protein
Neurology (clinical)
Developmental Biology
Endocrine gland
Hormone
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 1056
- Database :
- OpenAIRE
- Journal :
- Brain Research
- Accession number :
- edsair.doi.dedup.....994bf11a12f6f10f621b28de38903122