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Aversive Learning Increases Release Probability of Olfactory Sensory Neurons
- Source :
- Curr Biol
- Publication Year :
- 2019
- Publisher :
- Cold Spring Harbor Laboratory, 2019.
-
Abstract
- Predicting danger from previously associated sensory stimuli is essential for survival. Contributions from altered peripheral sensory inputs are implicated in this process, but the underlying mechanisms remain elusive. Here we use the mammalian olfactory system to investigate such mechanisms. Primary olfactory sensory neurons (OSNs) project their axons directly to the olfactory bulb (OB) glomeruli where their synaptic release is subject to local and cortical influence and neuromodulation. Pairing optogenetic activation of a single glomerulus with foot shock in mice induces freezing to the light stimulation alone during fear retrieval. This is accompanied by an increase in OSN release probability and a reduction in GABAB receptor expression in the conditioned glomerulus. Furthermore, freezing time is positively correlated with the release probability of OSNs in fear conditioned mice. These results suggest that aversive learning increases peripheral olfactory inputs at the first synapse, which may contribute to the behavioral outcome.
- Subjects :
- 0301 basic medicine
Male
Olfactory system
Olfactory Nerve
Neural facilitation
Sensory system
Optogenetics
Biology
GABAB receptor
General Biochemistry, Genetics and Molecular Biology
Article
Synapse
Mice
03 medical and health sciences
0302 clinical medicine
Neuromodulation
medicine
Animals
Learning
030304 developmental biology
Glomerulus (olfaction)
0303 health sciences
Fear
Olfactory Bulb
Olfactory bulb
030104 developmental biology
medicine.anatomical_structure
Conditioning, Operant
Female
General Agricultural and Biological Sciences
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Curr Biol
- Accession number :
- edsair.doi.dedup.....99429a43d177f8ccae4eb29ae875a991
- Full Text :
- https://doi.org/10.1101/642751