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Lack of association between an ecNOS gene polymorphism and diabetic nephropathy in type 2 diabetic patients with proliferative diabetic retinopathy
- Source :
- Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 32(2)
- Publication Year :
- 2000
-
Abstract
- The development of diabetic nephropathy shows remarkable variation among individuals. Therefore, not only hyperglycemia but also genetic factors may contribute to the development of diabetic nephropathy. The aim of the present study was to examine the contribution of the 27-bp repeat polymorphism in intron 4 of the endothelial constitutive nitric oxide synthase gene (ecNOS4) to the development of diabetic nephropathy. For this purpose, we analyzed this polymorphism in 167 Japanese type 2 diabetic patients with proliferative diabetic retinopathy consisting of 102 patients with diabetic nephropathy (with macroalbuminuria) and 65 patients without diabetic nephropathy (with normoalbuminuria). The genotype and allele frequencies were not significantly different between patients with diabetic nephropathy and those without diabetic nephropathy (ecNOS4 "b/b" 79.4% vs. 84.6%, ecNOS4 "b/a" 20.6% vs. 15.4%, "b" allele 89.7% vs. 92.3%, "a" allele 10.3% vs. 7.7%). We conclude that the ecNOS4 polymorphism does not contribute to the development of diabetic nephropathy.
- Subjects :
- Male
medicine.medical_specialty
Genotype
Nitric Oxide Synthase Type III
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Biochemistry
Diabetic nephropathy
Endocrinology
Internal medicine
medicine
Humans
Diabetic Nephropathies
Allele
Allele frequency
Alleles
Aged
Diabetic Retinopathy
Polymorphism, Genetic
business.industry
Biochemistry (medical)
General Medicine
Diabetic retinopathy
Middle Aged
medicine.disease
Endothelial Constitutive Nitric Oxide Synthase
Diabetes Mellitus, Type 2
Female
Gene polymorphism
Repeat polymorphism
Nitric Oxide Synthase
business
Subjects
Details
- ISSN :
- 00185043
- Volume :
- 32
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
- Accession number :
- edsair.doi.dedup.....9941b036ac13e1088208ca222e00a013