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Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from ginkgo biloba leaves
- Source :
- Planta medica. 65(5)
- Publication Year :
- 1999
-
Abstract
- Ginkgetin, a biflavone isolated from Ginkgo biloba leaves, was previously reported as an inhibitor of group II phospholipase A2. In this study, ginkgetin was evaluated for in vivo antiarthritic and analgesic activities. Ginkgetin (10-20 mg/kg/day) strongly reduced arthritic inflammation in an animal model of rat adjuvant-induced arthritis (86% inhibition at 16 days at a dose of 20 mg/kg/day) via intraperitoneal injection, while prednisolone (5 mg/kg/day) showed 79% reduction. Histological examination of the knee joints confirmed our findings. When analgesic activity was measured, ginkgetin showed a dose-dependent inhibition in an animal model of acetic acid-induced writhing. ED50 values for ginkgetin and indomethacin were 8.9 and 3.8 mg/kg, respectively. All these results indicate that ginkgetin may be a potential antiarthritic agent having analgesic activity.
- Subjects :
- Male
medicine.medical_treatment
Analgesic
Intraperitoneal injection
Indomethacin
Pharmaceutical Science
Arthritis
Pain
Pharmacology
Analytical Chemistry
law.invention
Rats, Sprague-Dawley
Mice
law
Drug Discovery
Medicine
Animals
Biflavonoids
Ginkgoales
ED50
Acetic Acid
Flavonoids
Analgesics
Mice, Inbred ICR
Plants, Medicinal
biology
Antiarthritic agent
Molecular Structure
business.industry
Ginkgo biloba
Plant Extracts
Organic Chemistry
Anti-Inflammatory Agents, Non-Steroidal
biology.organism_classification
medicine.disease
Arthritis, Experimental
Rats
Plant Leaves
Complementary and alternative medicine
Immunology
Molecular Medicine
business
Phytotherapy
Subjects
Details
- ISSN :
- 00320943
- Volume :
- 65
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Planta medica
- Accession number :
- edsair.doi.dedup.....994192740e006bf7873c36fd688bd263