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Genome diversity and instability in human germ cells and preimplantation embryos
- Source :
- Shukla, V, Høffding, M K & Hoffmann, E R 2021, ' Genome diversity and instability in human germ cells and preimplantation embryos ', Seminars in Cell and Developmental Biology, vol. 113, pp. 132-147 . https://doi.org/10.1016/j.semcdb.2020.12.007, Seminars in Cell & Developmental Biology
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Genome diversity is essential for evolution and is of fundamental importance to human health. Generating genome diversity requires phases of DNA damage and repair that can cause genome instability. Humans have a high incidence of de novo congenital disorders compared to other organisms. Recent access to eggs, sperm and preimplantation embryos is revealing unprecedented rates of genome instability that may result in infertility and de novo mutations that cause genomic imbalance in at least 70% of conceptions. The error type and incidence of de novo mutations differ during developmental stages and are influenced by differences in male and female meiosis. In females, DNA repair is a critical factor that determines fertility and reproductive lifespan. In males, aberrant meiotic recombination causes infertility, embryonic failure and pregnancy loss. Evidence suggest germ cells are remarkably diverse in the type of genome instability that they display and the DNA damage responses they deploy. Additionally, the initial embryonic cell cycles are characterized by a high degree of genome instability that cause congenital disorders and may limit the use of CRISPR-Cas9 for heritable genome editing.
- Subjects :
- 0301 basic medicine
Genome instability
Infertility
Rearrangements
DNA repair
DNA damage
Embryonic Development
Aneuploidy
Biology
DNA damage response
Genome
Article
Genomic Instability
03 medical and health sciences
0302 clinical medicine
Genome editing
medicine
Humans
Human oocytes and embryos
CNVs
Genetics
Genomic disorders
Cell Biology
medicine.disease
Germ Cells
030104 developmental biology
Homologous recombination
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- ISSN :
- 10849521
- Volume :
- 113
- Database :
- OpenAIRE
- Journal :
- Seminars in Cell & Developmental Biology
- Accession number :
- edsair.doi.dedup.....993ccc5178d17c191d6f8a25e2f2ca12