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Associations of HSP90AA2 gene polymorphisms with disease susceptibility, glucocorticoids efficacy and health-related quality of life in Chinese systemic lupus erythematosus patients
- Source :
- Genesgenomics. 40(10)
- Publication Year :
- 2018
-
Abstract
- Although the current glucocorticoids (GCs) treatment for systemic lupus erythematosus (SLE) is effective to a certain extent, the difference in therapeutic effect between patients is still a widespread problem. Some patients can have repeated attacks that greatly diminish their quality of life. This study was conducted to investigate the relationship between HSP90AA2 polymorphisms and disease susceptibility, GCs efficacy and health-related quality of life (HRQoL) in Chinese SLE patients. A case-control study was performed in 470 SLE patients and 470 normal controls. Then, 444 patients in the case group were followed up for 12 weeks to observe efficacy of GCs and improvement of HRQoL. Two single nucleotide polymorphisms (SNPs) of HSP90AA2 were selected for genotyping: rs1826330 and rs6484340. HRQoL was assessed using the SF-36 questionnaire. The minor T allele of rs1826330 and the TT haplotype formed by rs1826330 and rs6484340 showed associations with decreased SLE risk (T allele: PBH = 0.022; TT haplotype: PBH = 0.033). A significant association between rs6484340 and improvement of HRQoL was revealed in the follow-up study. Five subscales of SF-36 were appeared to be influenced by rs6484340: total score of SF-36 (additive model: PBH = 0.026), physical function (additive model: PBH = 0.026), role-physical (recessive model: PBH = 0.041), mental health (dominant model: PBH = 0.047), and physical component summary (additive model: PBH = 0.026). No statistical significance was found between HSP90AA2 gene polymorphisms and GCs efficacy. These results revealed a genetic association between HSP90AA2 and SLE. Remarkably, HSP90AA2 has an impact on the improvement of HRQoL in Chinese population with SLE.
- Subjects :
- 0301 basic medicine
Oncology
Adult
Male
medicine.medical_specialty
China
Genotyping Techniques
Single-nucleotide polymorphism
Biology
Biochemistry
Polymorphism, Single Nucleotide
03 medical and health sciences
Young Adult
0302 clinical medicine
Quality of life
Asian People
Statistical significance
Internal medicine
Genetics
medicine
Humans
Lupus Erythematosus, Systemic
Genetic Predisposition to Disease
HSP90 Heat-Shock Proteins
Allele
Molecular Biology
Genotyping
Glucocorticoids
Genetic Association Studies
Genetic association
030203 arthritis & rheumatology
Haplotype
Therapeutic effect
Middle Aged
030104 developmental biology
Treatment Outcome
Case-Control Studies
Quality of Life
Female
Subjects
Details
- ISSN :
- 20929293
- Volume :
- 40
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Genesgenomics
- Accession number :
- edsair.doi.dedup.....992e0d7d55f8d44cfdaaa24591252896