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Protective and restorative effects of sophorolipid on intestinal dystrophy in dextran sulfate sodium-induced colitis mouse model
- Source :
- Foodfunction. 13(1)
- Publication Year :
- 2021
-
Abstract
- The public has gradually begun to regard inflammatory bowel disease (IBD) as a crucial health issue; however, its mode of action has not been fully elucidated. Sophorolipid (SPL), a glycolipid-type biosurfactant, could be used as a potential treatment in physical intestinal dystrophy. We conducted a 2 × 2 factorial experiment to investigate the protective effect of SPL in a dextran sulfate sodium (DSS)-induced colitis mouse model (first factor, presence of SPL in feed; second factor, presence of DSS in water). Forty C57BL/6 mice (8-week-old) were used, and they were allocated to treatments according to their initial body weight. After a 7 d adjustment period, the DSS treatment was initiated in specific groups. At day 14, DSS was withdrawn from mice, and half of the mice were randomly selected and euthanized to collect colon and colon content samples. Three days after the end of DSS treatment, the rest of the mice were euthanized to investigate the therapeutic effect of SPL. Dietary SPL improved the growth performance in 3 d after DSS treatment, and the histopathological score was lower in the DSS-treated SPL group than in the DSS-treated control group. Mucosal thickness and goblet cell numbers significantly increased in the SPL-supplemented groups compared to in the control group. Similarly, SPL supplementation upregulated the gene expression levels of mucin-2, interleukin-10, and transforming growth factor-β, and increased the concentration of short chain fatty acid compared to the control groups. In conclusion, dietary supplementation with SPL attenuated the pathological response against acute and chronic inflammation by the maintenance of the mucosal barrier and wound healing capacity.
- Subjects :
- Inflammation
Oleic Acids
Pharmacology
Protective Agents
Inflammatory bowel disease
Mice
otorhinolaryngologic diseases
Medicine
Animals
Intestine, Large
Colitis
Intestinal Mucosa
Mode of action
Goblet cell
business.industry
Therapeutic effect
Dextran Sulfate
Dystrophy
General Medicine
medicine.disease
digestive system diseases
Mice, Inbred C57BL
Disease Models, Animal
medicine.anatomical_structure
Cytokines
medicine.symptom
business
Wound healing
Food Science
Subjects
Details
- ISSN :
- 2042650X
- Volume :
- 13
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Foodfunction
- Accession number :
- edsair.doi.dedup.....992d979d6654ab0c8dcffab74bc92a26