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Characteristics and impact of cardiovascular comorbidities on coronavirus disease 2019 in women: A multicentre cohort study
- Source :
- Archives of Cardiovascular Diseases
- Publication Year :
- 2021
- Publisher :
- Published by Elsevier Masson SAS., 2021.
-
Abstract
- Background. – Although women account for up to half of patients hospitalized for coronavirus disease 2019 (COVID-19), no specific data have been reported in this population. Aims. − To assess the burden and impact of cardiovascular comorbidities in women with COVID-19. Methods. − All consecutive patients hospitalized for COVID-19 across 24 hospitals from 26 February to 20 April 2020 were included. The primary composite outcome was transfer to an intensive care unit or in-hospital death. Results. − Among 2878 patients, 1212 (42.1%) were women. Women were older (68.3 ± 18.0 vs 65.4 ± 16.0 years; P < 0.001), but had less prevalent cardiovascular comorbidities than men. Among women, 276 (22.8%) experienced the primary outcome, including 161 (13.3%) transfers to an intensive care unit and 115 (9.5%) deaths without transfer to intensive care unit. The rate of in-hospital death or transfer to an intensive care unit was lower in women versus men (crude hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.53–0.72). Age (adjusted HR 1.05 per 5-year increase, 95% CI 1.01–1.10), body mass index (adjusted HR 1.06 per 2-unit increase, 95% CI 1.02–1.10), chronic kidney disease (adjusted HR 1.57, 95% CI 1.11–2.22) and heart failure (adjusted HR 1.52, 95% CI 1.04–2.22) were independently associated with the primary outcome in women. Elevated B-type natriuretic peptide/N-terminal prohormone of B-type natriuretic peptide (adjusted HR 2.41, 95% CI 1.70–3.44) and troponin (adjusted HR 2.00, 95% CI 1.39–2.88) concentrations at admission were also associated with the primary outcome, even in women free of previous coronary artery disease or heart failure. Conclusions. – Although female sex was associated with a lower risk of transfer to an intensive care unit or in-hospital death, COVID-19 remained associated with considerable morbimortality in women, especially in those with cardiovascular diseases.
- Subjects :
- Male
Comorbidity
030204 cardiovascular system & hematology
law.invention
0302 clinical medicine
law
Natriuretic Peptide, Brain
030212 general & internal medicine
Hospital Mortality
Résultats
COVID-19, coronavirus disease 2019
education.field_of_study
Smoking
General Medicine
Middle Aged
Intensive care unit
ICU, intensive care unit
Troponin
Intensive Care Units
Cardiovascular Diseases
Female
France
Cardiology and Cardiovascular Medicine
Risk assessment
Cohort study
medicine.medical_specialty
Population
Outcomes
Lower risk
Risk Assessment
SARS-CoV-2, severe acute respiratory syndrome coronavirus 2
Article
03 medical and health sciences
Facteurs de risque
Internal medicine
medicine
Diabetes Mellitus
Humans
Women
Sex Distribution
education
BNP, B-type natriuretic peptide
Aged
Proportional Hazards Models
Retrospective Studies
Proportional hazards model
business.industry
SARS-CoV-2
NT-proBNP, N-terminal prohormone of B-type natriuretic peptide
COVID-19
Retrospective cohort study
Length of Stay
medicine.disease
HR, hazard ratio
Asthma
Peptide Fragments
CI, confidence interval
Risk factors
Femmes
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 18752128 and 18752136
- Database :
- OpenAIRE
- Journal :
- Archives of Cardiovascular Diseases
- Accession number :
- edsair.doi.dedup.....9924b0cb61951ca931d50973b19bd5ac