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Characteristics and impact of cardiovascular comorbidities on coronavirus disease 2019 in women: A multicentre cohort study

Authors :
Delphine Mika
Sabir Attou
Théo Pezel
Gauthier Giordano
Vassili Panagides
Willy Sutter
Julie Pastier
Thomas Delmotte
C Fauvel
Antoine Deney
Alexandre Gautier
Guillaume Bonnet
Joffrey Cellier
Antonin Trimaille
Victor Waldmann
Pierre Guilleminot
Baptiste Duceau
Pascale Chemaly
Clément Karsenty
Sophie Ribeyrolles
Orianne Weizman
Thibaut Pommier
C. Chaumont
Wassima Marsou
Ariel Cohen
Audrey Sagnard
Laura Geneste
Source :
Archives of Cardiovascular Diseases
Publication Year :
2021
Publisher :
Published by Elsevier Masson SAS., 2021.

Abstract

Background. – Although women account for up to half of patients hospitalized for coronavirus disease 2019 (COVID-19), no specific data have been reported in this population. Aims. − To assess the burden and impact of cardiovascular comorbidities in women with COVID-19. Methods. − All consecutive patients hospitalized for COVID-19 across 24 hospitals from 26 February to 20 April 2020 were included. The primary composite outcome was transfer to an intensive care unit or in-hospital death. Results. − Among 2878 patients, 1212 (42.1%) were women. Women were older (68.3 ± 18.0 vs 65.4 ± 16.0 years; P < 0.001), but had less prevalent cardiovascular comorbidities than men. Among women, 276 (22.8%) experienced the primary outcome, including 161 (13.3%) transfers to an intensive care unit and 115 (9.5%) deaths without transfer to intensive care unit. The rate of in-hospital death or transfer to an intensive care unit was lower in women versus men (crude hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.53–0.72). Age (adjusted HR 1.05 per 5-year increase, 95% CI 1.01–1.10), body mass index (adjusted HR 1.06 per 2-unit increase, 95% CI 1.02–1.10), chronic kidney disease (adjusted HR 1.57, 95% CI 1.11–2.22) and heart failure (adjusted HR 1.52, 95% CI 1.04–2.22) were independently associated with the primary outcome in women. Elevated B-type natriuretic peptide/N-terminal prohormone of B-type natriuretic peptide (adjusted HR 2.41, 95% CI 1.70–3.44) and troponin (adjusted HR 2.00, 95% CI 1.39–2.88) concentrations at admission were also associated with the primary outcome, even in women free of previous coronary artery disease or heart failure. Conclusions. – Although female sex was associated with a lower risk of transfer to an intensive care unit or in-hospital death, COVID-19 remained associated with considerable morbimortality in women, especially in those with cardiovascular diseases.

Details

Language :
English
ISSN :
18752128 and 18752136
Database :
OpenAIRE
Journal :
Archives of Cardiovascular Diseases
Accession number :
edsair.doi.dedup.....9924b0cb61951ca931d50973b19bd5ac