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The effects of carvacrol on oxidative stress, inflammation, and liver function indicators in a systemic inflammation model induced by lipopolysaccharide in rats
- Source :
- International Journal for Vitamin and Nutrition Research. 93:111-121
- Publication Year :
- 2023
- Publisher :
- Hogrefe Publishing Group, 2023.
-
Abstract
- Abstract: The effect of carvacrol (CAR) on oxidative stress, inflammation, and liver dysfunction induced by lipopolysaccharide (LPS) was explored. The rats (n=40) were daily injected (2 weeks) by saline as control, LPS (1 mg/kg, i.p.), and 25, 50 or 100 mg/kg CAR (i.p.) before LPS. LPS increased aspartate transaminase (AST: 162±13 U/L), alanine aminotransferase (ALT: 74.6±2.15 U/L), alkaline phosphatase (ALK-P: 811±51 U/L), interlukine-1β (IL-1β: 1254±51 pg/g tissue), malondialdehyde (MDA: 32±1.09 nM/g tissue), and nitric oxide (NO: 224±13.5 nM/g tissue) (P
- Subjects :
- 0301 basic medicine
Nutrition and Dietetics
Lipopolysaccharide
business.industry
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Inflammation
General Medicine
Pharmacology
medicine.disease_cause
Systemic inflammation
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
0302 clinical medicine
chemistry
030220 oncology & carcinogenesis
medicine
Carvacrol
Liver function
medicine.symptom
Liver dysfunction
business
Oxidative stress
Subjects
Details
- ISSN :
- 16642821 and 03009831
- Volume :
- 93
- Database :
- OpenAIRE
- Journal :
- International Journal for Vitamin and Nutrition Research
- Accession number :
- edsair.doi.dedup.....991d0123a9ee210429a06f0a5c59fab7