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Association of lymph node involvement with the prognosis of pathological T1 invasive non-small cell lung cancer
- Source :
- World Journal of Surgical Oncology
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Background Lymph node involvement could help to predict the prognosis of pathological T1 (pT1, diameters of ≤3 cm) non-small cell lung cancer (NSCLC). This study assessed the clinicopathological factors and associated lymph node involvement in invasive lung adenocarcinoma (IAC) and squamous cell lung cancer (SCC) and the overall and disease-free survival associated with these factors. Methods Three hundred and twenty-five patients with pathological T1 NSCLC (253 IAC and 72 SCC) were retrospectively analyzed from a pool of 1094 primary lung cancer patients. The data were assessed using multiple logistic regression, Kaplan-Meier curves and multivariable analyses. Results Among patients with a ≤30-mm tumor lesion (N = 325), N1 and N2 lymph node involvement was found in 28 (8.6%) and 34 (10.4%) patients, respectively. Lymph node metastasis occurred in 13.0% (33/253) of pT1 IAC patients and 40.3% (29/72) of SCC patients. Carcinoembryonic antigen (CEA) levels, SCC by histology, and tumor lesions larger than 1.0 cm were associated with lymph node involvement (P
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Lung Neoplasms
medicine.medical_treatment
Adenocarcinoma
030204 cardiovascular system & hematology
NSCLC
03 medical and health sciences
0302 clinical medicine
Carcinoembryonic antigen
Surgical oncology
Carcinoma, Non-Small-Cell Lung
Internal medicine
medicine
Humans
Pathological T1 disease
Pneumonectomy
Lung cancer
Lymph node
Aged
Neoplasm Staging
Retrospective Studies
Aged, 80 and over
Lymph node metastasis
Chemotherapy
Lung
biology
business.industry
Research
Middle Aged
Prognosis
medicine.disease
Survival Rate
medicine.anatomical_structure
Lymphatic Metastasis
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
biology.protein
Lymph Node Excision
Female
Surgery
Lymph Nodes
Lymph
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 14777819
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- World Journal of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....991c34a5334e74c18ab7141e992f123b