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Elevated intracranial dopamine impairs the glutamate-nitric oxide-cyclic guanosine monophosphate pathway in cortical astrocytes in rats with minimal hepatic encephalopathy
- Source :
- Molecular Medicine Reports
- Publication Year :
- 2014
- Publisher :
- D.A. Spandidos, 2014.
-
Abstract
- In a previous study by our group memory impairment in rats with minimal hepatic encephalopathy (MHE) was associated with the inhibition of the glutamate-nitric oxide-cyclic guanosine monophosphate (Glu-NO-cGMP) pathway due to elevated dopamine (DA). However, the effects of DA on the Glu-NO-cGMP pathway localized in primary cortical astrocytes (PCAs) had not been elucidated in rats with MHE. In the present study, it was identified that when the levels of DA in the cerebral cortex of rats with MHE and high-dose DA (3 mg/kg)-treated rats were increased, the co-localization of N-methyl-d-aspartate receptors subunit 1 (NMDAR1), calmodulin (CaM), nitric oxide synthase (nNOS), soluble guanylyl cyclase (sGC) and cyclic guanine monophosphate (cGMP) with the glial fibrillary acidic protein (GFAP), a marker protein of astrocytes, all significantly decreased, in both the MHE and high-dose DA-treated rats (P
- Subjects :
- Cancer Research
Dopamine
minimal hepatic encephalopathy
Receptors, Cytoplasmic and Nuclear
Biochemistry
Rats, Sprague-Dawley
chemistry.chemical_compound
Soluble Guanylyl Cyclase
primary cortical astrocytes
Glutamates
Cyclic GMP
Cerebral Cortex
Glial fibrillary acidic protein
Behavior, Animal
Glutamate receptor
Articles
Nitric oxide synthase
medicine.anatomical_structure
Oncology
Cerebral cortex
Molecular Medicine
Signal Transduction
medicine.medical_specialty
N-Methylaspartate
Biology
Nitric Oxide
Receptors, N-Methyl-D-Aspartate
Nitric oxide
Calmodulin
Memory
Internal medicine
Guanosine monophosphate
Glial Fibrillary Acidic Protein
Genetics
medicine
Animals
Molecular Biology
Cyclic guanosine monophosphate
Dose-Response Relationship, Drug
Rats
Disease Models, Animal
Endocrinology
chemistry
Guanylate Cyclase
Astrocytes
Hepatic Encephalopathy
biology.protein
glutamate-nitric oxide-cyclic guanosine monophosphate
Nitric Oxide Synthase
Soluble guanylyl cyclase
Subjects
Details
- Language :
- English
- ISSN :
- 17913004 and 17912997
- Volume :
- 10
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Molecular Medicine Reports
- Accession number :
- edsair.doi.dedup.....9911956fd0cf7ef5032915b6a6c39f68