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CCR5 or CXCR4 use influences the relationship between CD4 cell depletion, NKp44L expression and NK cytotoxicity in SHIV-infected macaques
- Source :
- AIDS. 22:185-192
- Publication Year :
- 2008
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2008.
-
Abstract
- Objective: HIV-1 infection is characterized by a progressive decline of CD4 cell count, the underlying mechanisms of which are still debated. We recently found that during HIV-1 infection, CD4 T cells overexpress a ligand of the NK activating receptor NKp44 (NKp44L) and are sensitized to NK cytolytic activity. The expression of NKp44L is triggered by a highly conserved motif of gp41 (3S) and is inhibited by anti-3S antibodies. Design: To assess whether viral tropism can affect NKp44L expression, NK cytotoxicity, and anti-3S antibodies production, 10 macaques were infected either with the CCR5 tropic SHIV 162P3 or with a CXCR4/CCR5 dual-tropic SHIV 89.6 P. Results: In SHlV 162P3 -infected macaques, expression of NKp44L was inversely correlated with anti-3S antibodies, in relation to CD4 depletion and NK cytotoxicity. By contrast, no such correlation was found in macaques infected with SHIV 89.6p which, induced a rapid decline of CD4 T cells. Conclusions: These results highlight the key role played by NK cells in CD4 cell count decline with respect to coreceptor usage, and provided the setting to investigate new strategies for preventive and/or therapeutic immunization to stimulate anti-3S antibodies.
- Subjects :
- CD4-Positive T-Lymphocytes
Receptors, CXCR4
Receptors, CCR4
Receptors, CCR5
viruses
Amino Acid Motifs
Immunology
Simian Acquired Immunodeficiency Syndrome
Biology
Antibodies, Viral
medicine.disease_cause
CXCR4
Natural killer cell
medicine
Animals
Immunology and Allergy
Receptors, Immunologic
Cytotoxicity
Tropism
Natural Cytotoxicity Triggering Receptor 2
virus diseases
Simian immunodeficiency virus
Cytotoxicity Tests, Immunologic
Virology
HIV Envelope Protein gp41
CD4 Lymphocyte Count
Killer Cells, Natural
Macaca fascicularis
Cytolysis
Infectious Diseases
medicine.anatomical_structure
Tissue tropism
biology.protein
Simian Immunodeficiency Virus
Antibody
Reassortant Viruses
Subjects
Details
- ISSN :
- 02699370
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- AIDS
- Accession number :
- edsair.doi.dedup.....990a05939403737f82649d7b32bba007