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Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Evidence suggests that selective serotonin reuptake inhibitors (SSRIs) reorganize neural networks via a transient window of neuroplasticity. While previous findings support an effect of SSRIs on intrinsic functional connectivity, little is known regarding the influence of SSRI-administration on connectivity during sequence motor learning. To investigate this, we administered 20 mg escitalopram or placebo for 1-week to 60 healthy female participants undergoing concurrent functional magnetic resonance imaging and sequence motor training in a double-blind randomized controlled design. We assessed task-modulated functional connectivity with a psycho-physiological interaction (PPI) analysis in the thalamus, putamen, cerebellum, dorsal premotor, primary motor, supplementary motor, and dorsolateral prefrontal cortices. Comparing an implicit sequence learning condition to a control learning condition, we observed decreased connectivity between the thalamus and bilateral motor regions after 7 days of escitalopram intake. Additionally, we observed a negative correlation between plasma escitalopram levels and PPI connectivity changes, with higher escitalopram levels being associated with greater thalamo-cortico decreases. Our results suggest that escitalopram enhances network-level processing efficiency during sequence motor learning, despite no changes in behaviour. Future studies in more diverse samples, however, with quantitative imaging of neurochemical markers of excitation and inhibition, are necessary to further assess neural responses to escitalopram.
- Subjects :
- Adult
Male
Science
Citalopram
Article
Learning and memory
Young Adult
03 medical and health sciences
0302 clinical medicine
Neurochemical
Thalamus
Motor control
Cerebellum
Neuroplasticity
mental disorders
medicine
Humans
Learning
Escitalopram
030304 developmental biology
Motor Neurons
Pharmacology
0303 health sciences
Neuronal Plasticity
Multidisciplinary
medicine.diagnostic_test
business.industry
Putamen
Neurochemistry
Magnetic Resonance Imaging
Medicine
Female
Sequence learning
Nerve Net
Motor learning
business
Functional magnetic resonance imaging
Neuroscience
Selective Serotonin Reuptake Inhibitors
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....9906572ba2b4e919802aec09a839b23a