Back to Search
Start Over
Intermittent hypoxia-related alterations in vascular structure and function: a systematic review and metaanalysis of rodent data
- Source :
- European Respiratory Journal, European Respiratory Journal, European Respiratory Society, 2021, 58 (4), pp.2100866. ⟨10.1183/13993003.00866-2021⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- BackgroundObstructive sleep apnoea and the related intermittent hypoxia (IH) are widely recognised as risk factors for incident cardiovascular diseases. Numerous studies support the deleterious vascular impact of IH in rodents but an overall interpretation is challenging owing to heterogeneity in rodent species investigated and the severity and duration of IH exposure. To clarify this major issue, we conducted a systematic review and meta-analysis to quantify the impact of IH on systemic artery structure and function depending on the different IH exposure designs.MethodsWe searched PubMed, Embase and Web of Science, and included 125 articles in a meta-analysis, among them 112 using wild-type rodents and 13 using apolipoprotein E knockout (ApoE−/−) mice. We used the standardised mean difference (SMD) to compare results between studies.ResultsIH significantly increased mean arterial pressure (+13.90 (95% CI 11.88–15.92) mmHg), and systolic and diastolic blood pressure. Meta-regressions showed that mean arterial pressure change was associated with strain and year of publication. IH altered vasodilation in males but not in females and increased endothelin-1-induced but not phenylephrine-induced vasoconstriction. Intima–media thickness significantly increased upon IH exposure (SMD 1.10 (95% CI 0.58–1.62); absolute values +5.23 (2.81–7.84) µm). This increase was observed in mice but not in rats and was negatively associated with age. Finally, IH increased atherosclerotic plaque size in ApoE−/− mice (SMD 1.08 (95% CI 0.80–1.37)).ConclusionsOur meta-analysis established that IH, independently of other confounders, has a strong effect on vascular structure and physiology. Our findings support the interest of identifying and treating sleep apnoea in routine cardiology practice.
- Subjects :
- Pulmonary and Respiratory Medicine
Male
medicine.medical_specialty
Mean arterial pressure
vascular reactivity
vascular remodeling
intermittent hypoxia
Vasodilation
Blood Pressure
Rodentia
Carotid Intima-Media Thickness
03 medical and health sciences
Mice
0302 clinical medicine
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Internal medicine
[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
Medicine
Animals
Humans
030212 general & internal medicine
Hypoxia
business.industry
Sleep apnea
Intermittent hypoxia
medicine.disease
3. Good health
Rats
Obstructive sleep apnea
meta-analysis
Disease Models, Animal
Blood pressure
medicine.anatomical_structure
030228 respiratory system
Cardiology
Female
medicine.symptom
arterial pressure
business
European Respiratory Journal systematic review
Vasoconstriction
Artery
Subjects
Details
- Language :
- English
- ISSN :
- 09031936 and 13993003
- Database :
- OpenAIRE
- Journal :
- European Respiratory Journal, European Respiratory Journal, European Respiratory Society, 2021, 58 (4), pp.2100866. ⟨10.1183/13993003.00866-2021⟩
- Accession number :
- edsair.doi.dedup.....98f811f177a02ffadb113ca98e32583b