Corneal neovascularization possibly associated with latanoprost therapy

PURPOSE. To report a case of corneal neovascularization possibly associated with latanoprost therapy. METHODS. Case report: A 67-year-old man developed a progressive stromal corneal neovascularization in his right eye within eight months of a corneal trauma. At admission, he was receiving latanoprost 0.005% therapy. His topical medications were rearranged: latanoprost was replaced with carteolol hydrochloride 1% twice daily bilaterally and prednisolone acetate 1% was added twice daily in the right eye. RESULTS. One month later, he presented regression of the corneal neovascularization and an increase in visual acuity. CONCLUSIONS. Latanoprost, an arachidonic acid derivative, could have directly or indirectly stimulated the corneal neovascularization in this patient with a history of nonpenetrating corneal trauma.