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Production of Hydroxy Acids
- Source :
- Angewandte Chemie (International Ed. in English), Angewandte Chemie (International ed. in English), 59(12), 4869-4872. WILEY-V C H VERLAG GMBH
- Publication Year :
- 2020
- Publisher :
- WILEY-V C H VERLAG GMBH, 2020.
-
Abstract
- Flavoprotein oxidases can catalyze oxidations of alcohols and amines by merely using molecular oxygen as the oxidant, making this class of enzymes appealing for biocatalysis. The FAD‐containing (FAD=flavin adenine dinucleotide) alcohol oxidase from P. chrysosporium facilitated double and triple oxidations for a range of aliphatic diols. Interestingly, depending on the diol substrate, these reactions result in formation of either lactones or hydroxy acids. For example, diethylene glycol could be selectively and fully converted into 2‐(2‐hydroxyethoxy)acetic acid. Such a facile cofactor‐independent biocatalytic route towards hydroxy acids opens up new avenues for the preparation of polyester building blocks.<br />Triple action: The flavoprotein alcohol oxidase (AOX*) facilitates the double and triple oxidations of diols. Interestingly, depending on the diol substrate, these reactions result in formation of either lactones or hydroxy acids. Such biocatalytic route towards hydroxy acids has potential for the preparation of polyester building blocks.
- Subjects :
- biocatalysis
oxidation
Diol
enzymes
Flavoprotein
diols
010402 general chemistry
01 natural sciences
Catalysis
lactones
chemistry.chemical_compound
Acetic acid
Organic chemistry
Flavin adenine dinucleotide
chemistry.chemical_classification
Flavoproteins
Molecular Structure
biology
010405 organic chemistry
Basidiomycota
Communication
Diethylene glycol
General Medicine
General Chemistry
Communications
0104 chemical sciences
Alcohol oxidase
Alcohol Oxidoreductases
chemistry
Biocatalysis
Alcohols
biology.protein
Hydroxy Acids
Oxidation-Reduction
Lactone
Subjects
Details
- Language :
- English
- ISSN :
- 15213773 and 14337851
- Volume :
- 59
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie - International Edition
- Accession number :
- edsair.doi.dedup.....98f6a50ca5591f5ae1e943aad612423f