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Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis
- Source :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 11(11)
- Publication Year :
- 2011
-
Abstract
- Primary graft dysfunction (PGD) after lung transplantation may result from ischemia reperfusion injury (IRI). The innate immune response to IRI may be mediated by Toll-like receptor and IL-1-induced long pentraxin-3 (PTX3) release. We hypothesized that elevated PTX3 levels were associated with PGD. We performed a nested case control study of lung transplant recipients with idiopathic pulmonary fibrosis (IPF) or chronic obstructive pulmonary disease (COPD) from the Lung Transplant Outcomes Group cohort. PTX3 levels were measured pretransplant, and 6 and 24 h postreperfusion. Cases were subjects with grade 3 PGD within 72 h of transplantation and controls were those without grade 3 PGD. Generalized estimating equations and multivariable logistic regression were used for analysis. We selected 40 PGD cases and 79 non-PGD controls. Plasma PTX3 level was associated with PGD in IPF but not COPD recipients (p for interaction < 0.03). Among patients with IPF, PTX3 levels at 6 and 24 h were associated with PGD (OR = 1.6, p = 0.02 at 6 h; OR = 1.4, p = 0.008 at 24 h). Elevated PTX3 levels were associated with the development of PGD after lung transplantation in IPF patients. Future studies evaluating the role of innate immune activation in IPF and PGD are warranted.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Primary Graft Dysfunction
Gastroenterology
Article
Idiopathic pulmonary fibrosis
Pulmonary Disease, Chronic Obstructive
Internal medicine
medicine
Immunology and Allergy
Lung transplantation
Humans
Pharmacology (medical)
Transplantation
COPD
Lung
biology
business.industry
C-reactive protein
respiratory system
Middle Aged
medicine.disease
Idiopathic Pulmonary Fibrosis
Immunity, Innate
respiratory tract diseases
Serum Amyloid P-Component
medicine.anatomical_structure
C-Reactive Protein
Case-Control Studies
Reperfusion Injury
Immunology
Nested case-control study
biology.protein
lipids (amino acids, peptides, and proteins)
Female
business
Lung Transplantation
Subjects
Details
- ISSN :
- 16006143
- Volume :
- 11
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
- Accession number :
- edsair.doi.dedup.....98f456e0370a32051b150c09ffd3c7ba