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Expression of mouse liver receptor homologue 1 in embryonic stem cells is directed by a novel promoter
- Source :
- FEBS Letters. 580:1702-1708
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- Liver receptor homologue 1 (LRH-1) plays important roles in many physiological processes and embryogenesis. However, little is known about the developmental regulation of lrh-1 expression. We identified a novel transcript of mouse lrh-1 (mlrh-1v2) from embryonic stem (ES) cells. mlrh-1v2 is expressed throughout embryogenesis and in several adult tissues, while the known transcript (mlrh-1v1) appears later during embryogenesis. mlrh-1v2 expression is directed by a new promoter which displays a strong activity in ES cells. The generation of the new transcript is conserved in rats. The identification of novel mlrh-1 variant and promoter is critical for elucidating LRH-1 functions in development and adult tissues.
- Subjects :
- Molecular Sequence Data
Biophysics
Embryonic Development
Receptors, Cytoplasmic and Nuclear
Biology
Biochemistry
mLRH-1
Cell Line
Conserved sequence
Mice
Rapid amplification of cDNA ends
Structural Biology
Genetics
Animals
Rats, Wistar
Promoter Regions, Genetic
Receptor
Molecular Biology
Conserved Sequence
Regulation of gene expression
Base Sequence
Stem Cells
Embryogenesis
Promoter
Gene Expression Regulation, Developmental
Genetic Variation
Embryo
Cell Biology
Transcript
Embryo, Mammalian
Molecular biology
Embryonic stem cell
Rats
Cell culture
Subjects
Details
- ISSN :
- 00145793
- Volume :
- 580
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....98f37dca764a1a61c8212156d4d5f8db