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Candidate-gene association analysis of response to risperidone in African-American and white patients with schizophrenia
- Source :
- The Pharmacogenomics Journal. 9:311-318
- Publication Year :
- 2009
- Publisher :
- Springer Science and Business Media LLC, 2009.
-
Abstract
- Clinical trial data were evaluated for the association between 22 single-nucleotide polymorphisms (SNPs) and response in acutely ill patients diagnosed with schizophrenia, schizoaffective disorder or schizophreniform disorder, who were treated with oral risperidone. All patients in the exploratory (78 African Americans) and validation (65 whites) data sets received risperidone 2-6 mg per day over 2-12 weeks. Two SNPs were found to have significant associations with response to risperidone over 2-12 weeks in both African-American and white patients and had a consistent direction of effect in both cohorts. Metabotropic glutamate receptor (GRM3) SNP, rs724226, was associated with a change in the positive and negative syndrome scale (PANSS) total response. Catechol-O-methyltransferase (COMT) SNP, rs165599, was moderately associated with a change in the PANSS Negative score. The greater prevalence of poor-responder GRM3 and COMT alleles in white versus African-American patients might have a clinical significance in evaluating the ethnic-specific response to risperidone.
- Subjects :
- Adult
Male
Olanzapine
medicine.medical_specialty
Time Factors
medicine.drug_class
Administration, Oral
Atypical antipsychotic
Schizoaffective disorder
Catechol O-Methyltransferase
Receptors, Metabotropic Glutamate
Polymorphism, Single Nucleotide
White People
Double-Blind Method
Internal medicine
Genetics
medicine
Humans
Schizophreniform disorder
Genetic Association Studies
Clozapine
Psychiatric Status Rating Scales
Pharmacology
Risperidone
Positive and Negative Syndrome Scale
business.industry
Middle Aged
medicine.disease
Black or African American
Treatment Outcome
Pharmacogenetics
Schizophrenia
Molecular Medicine
Female
Schizophrenic Psychology
business
Antipsychotic Agents
medicine.drug
Subjects
Details
- ISSN :
- 14731150 and 1470269X
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- The Pharmacogenomics Journal
- Accession number :
- edsair.doi.dedup.....98da64de9757f7a5a9bfaf6ff44cf665