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Low serum level of secreted frizzled-related protein 5, an anti-inflammatory adipokine, is associated with coronary artery disease
- Source :
- Atherosclerosis. 233(2)
- Publication Year :
- 2013
-
Abstract
- Objective Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine that is associated with insulin resistance in animals. To extend these observations to humans, we investigated the association of serum SFRP5 levels in subjects with and without coronary artery disease (CAD). Methods Subjects (n = 185, 68 ± 11 years, 79% male) suspected of having CAD were enrolled in the study and were divided into two groups, CAD and non-CAD subjects, according to the results of their coronary angiographies. Serum SFRP5 levels of the subjects were measured by an enzyme-linked immunosorbent assay. Results The serum SFRP5 levels in the subjects with CAD were significantly lower than those in the non-CAD subjects (median [interquartile range]: 47.7 [26.6] vs. 52.4 [29.6] ng/mL, respectively; p = 0.02). The serum SFRP5 levels significantly correlated with body mass index, the homeostasis model of assessment of insulin resistance, adiponectin levels, and CAD severity. Multivariate logistic regression analysis revealed that a decreased serum SFRP5 level (log transformed) was independently associated with CAD for all subjects (adjusted odds ratio, 0.36; 95% confidence interval, 0.14–0.94; p = 0.03). Conclusion Serum SFRP5 levels are significantly associated with CAD in humans, suggesting that low SFRP5 levels may contribute to CAD.
- Subjects :
- Male
medicine.medical_specialty
Adipokine
Comorbidity
Coronary Artery Disease
Coronary Angiography
Body Mass Index
Coronary artery disease
Insulin resistance
Adipokines
Japan
Interquartile range
Risk Factors
Internal medicine
medicine
Diabetes Mellitus
Humans
cardiovascular diseases
Obesity
Eye Proteins
Adaptor Proteins, Signal Transducing
Aged
Dyslipidemias
Adiponectin
business.industry
Smoking
Membrane Proteins
Odds ratio
Middle Aged
medicine.disease
Confidence interval
Endocrinology
Hypertension
Female
Insulin Resistance
Cardiology and Cardiovascular Medicine
business
Body mass index
Subjects
Details
- ISSN :
- 18791484
- Volume :
- 233
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Atherosclerosis
- Accession number :
- edsair.doi.dedup.....98d2a374618b8f73676687a001a463d2