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Usefulness of Aquaporin 1 as a Prognostic Marker in a Prospective Cohort of Malignant Mesotheliomas
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 17, Iss 7, p 1041 (2016)
- Publication Year :
- 2016
-
Abstract
- (1) Background: Malignant mesothelioma (MM) is an aggressive tumour of the serosal membranes, associated with exposure to asbestos. Survival is generally poor, but prognostication for individual patients is difficult. We recently described Aquaporin 1 (AQP1) as independent prognostic factor in two separate retrospective cohorts of MM patients. Here we assess the usefulness of AQP1 prospectively, and determine the inter-observer agreement in assessing AQP1 scores; (2) Methods: A total of 104 consecutive cases of MM were included. Sufficient tissue for immunohistochemistry was available for 100 cases, and these cases were labelled for AQP1. Labelling was assessed by two pathologists. Complete clinical information and follow up was available for 91 cases; (3) Results: Labelling of ≥50% of tumour cells for AQP indicated improved prognosis in a univariate model (median survival 13 versus 8 months, p = 0.008), but the significance was decreased in a multivariate analysis. Scoring for AQP1 was robust, with an inter-observer kappa value of 0.722, indicating substantial agreement between observers; (4) Conclusion: AQP1 is a useful prognostic marker that can be easily incorporated in existing diagnostic immunohistochemical panels and which can be reliably interpreted by different pathologists.
- Subjects :
- 0301 basic medicine
Oncology
Male
Mesothelioma
Pathology
Multivariate analysis
Lung Neoplasms
Kaplan-Meier Estimate
lcsh:Chemistry
0302 clinical medicine
Prospective Studies
Prospective cohort study
lcsh:QH301-705.5
Spectroscopy
Aged, 80 and over
Kappa value
Communication
General Medicine
Middle Aged
Prognosis
peritoneum
Immunohistochemistry
Computer Science Applications
pleura
030220 oncology & carcinogenesis
Aquaporin 1
malignant mesothelioma
Female
Median survival
Adult
medicine.medical_specialty
Catalysis
Inorganic Chemistry
03 medical and health sciences
Internal medicine
medicine
Biomarkers, Tumor
Humans
Physical and Theoretical Chemistry
Molecular Biology
Aged
Proportional Hazards Models
Proportional hazards model
business.industry
Organic Chemistry
Mesothelioma, Malignant
medicine.disease
asbestos
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Multivariate Analysis
business
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 17
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....98cf662a23b594a14918268e38a8232a