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Maternotoxicity and fetotoxicity in <scp>Rattus norvegicus</scp> albinus exposed to tramadol during the late phase of pregnancy
- Source :
- Birth Defects Research. 113:1407-1421
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- OBJECTIVES Tramadol, an atypical opioid, is clinically efficacious in treating moderate to severe pain. The aim of current study was to find out the toxicological effects of tramadol exposure to pregnant rats and fetuses during the late phase of pregnancy. METHODS Wistar pregnant rats were exposed to 1.25, 2.5, or 5 mg/kg/day tramadol from 14th to 20th day of pregnancy. The same therapy was given to nonpregnant rats for 7 days. The body weight, oral glucose and lipid tolerance tests, and effect on complete blood parameters in both pregnant and nonpregnant rats were determined. On 20th day, maternal placentas were excised and weighed while fetuses were observed for any deformity and growth retardation. Oxidative stress biomarkers were estimated in the liver and kidney tissue homogenates of the pregnant and nonpregnant rats while the whole fetus homogenate was processed for the same. Moreover, histopathology of the liver and kidney of pregnant and nonpregnant rats were carried out. RESULTS Tramadol administration did not significantly alter the area under curve of the blood glucose and triglyceride levels in both the pregnant and nonpregnant rats. It reduced the live fetuses, placental weights, fetal length, and fetal weights. Tramadol treated pregnant rats showed significantly (p
- Subjects :
- Embryology
medicine.medical_specialty
Placenta
Health, Toxicology and Mutagenesis
Physiology
Hematocrit
Kidney
Toxicology
chemistry.chemical_compound
Fetus
Pregnancy
medicine
Animals
Rats, Wistar
Tramadol
reproductive and urinary physiology
medicine.diagnostic_test
Triglyceride
business.industry
medicine.disease
Malondialdehyde
Rats
chemistry
Pediatrics, Perinatology and Child Health
Female
Histopathology
Lipid profile
business
Developmental Biology
medicine.drug
Subjects
Details
- ISSN :
- 24721727
- Volume :
- 113
- Database :
- OpenAIRE
- Journal :
- Birth Defects Research
- Accession number :
- edsair.doi.dedup.....98cac48fc07f3751679475ba2bcd10db