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Expression of pro-inflammatory TACE-TNF-α-amphiregulin axis in Sjögren’s syndrome salivary glands
- Source :
- Histochemistry and Cell Biology. 134:345-353
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- The tumor-necrosis-factor-converting-enzyme (TACE)-TNF-alpha-Amphiregulin (AREG) axis plays an important pathogenic role in inflammatory and autoimmune disorders. However, the pathological roles of these proteins in the chronic autoimmune disease Sjogren's syndrome (SS) remain to be elucidated. It is known that the TACE-AREG axis is clearly part of a larger cascade of signals that starts with the activation of Furin, responsible for maturation of TACE that, in turn, determines the production of active TNF-alpha, directly involved in the up-regulation of AREG expression. This study showed that Furin, TACE, TNF-alpha, and AREG proteins, detected in acinar and ductal cells of human salivary glands from SS patients, increased remarkably in comparison with biopsies of labial salivary glands from healthy controls. The changes in Furin, TACE, TNF- alpha, and AREG proteins' level detected in salivary glands biopsies of SS patients could be responsible for pro-inflammatory cytokines overexpression characterizing Sjogren's syndrome.
- Subjects :
- EGF Family of Proteins
medicine.medical_specialty
DNA, Complementary
Histology
Ductal cells
Blotting, Western
Inflammation
ADAM17 Protein
Biology
Amphiregulin
Salivary Glands
stomatognathic system
Internal medicine
medicine
Humans
Molecular Biology
Furin
Glycoproteins
Salivary gland
Autoimmune disease
Base Sequence
Reverse Transcriptase Polymerase Chain Reaction
Tumor Necrosis Factor-alpha
Cell Biology
medicine.disease
Immunohistochemistry
ADAM Proteins
Medical Laboratory Technology
Sjogren's Syndrome
medicine.anatomical_structure
Endocrinology
biology.protein
Cytokines
Intercellular Signaling Peptides and Proteins
Sjögren's syndrome
Tumor necrosis factor alpha
Tumor-necrosis-factor-converting-enzyme
medicine.symptom
Sequence Analysis
TNF-alpha
Subjects
Details
- ISSN :
- 1432119X and 09486143
- Volume :
- 134
- Database :
- OpenAIRE
- Journal :
- Histochemistry and Cell Biology
- Accession number :
- edsair.doi.dedup.....98c3a6abf46231afb40e054ef3f430ad