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Conflicts of Interest and Clinical Recommendations
- Source :
- American Journal of Medical Quality. 29:53-60
- Publication Year :
- 2013
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2013.
-
Abstract
- The growing influence of practice guidelines has increased concern for potential sources of bias. Two recent guidelines for primary immune thrombocytopenia (ITP) provided a unique opportunity for a systematic comparison of different methods of practice guideline development. One guideline (International Consensus Report [ICR]) was supported by pharmaceutical companies that produce products for ITP. The ICR panel members were selected for expertise in ITP; 16 (73%) reported associations with pharmaceutical companies. The other guideline was sponsored by the American Society of Hematology (ASH); panel members were selected for lack of conflicts and for expertise in guideline development as well as for ITP. Discrepancies were conspicuous when the guidelines addressed treatment. In contrast to the ASH guideline, the ICR gave stronger recommendations for agents manufactured by companies from which the ICR or its panel members received support. These data provide direct evidence that differences in financial support and methods of evidence evaluation can influence recommendations.
- Subjects :
- Adult
medicine.medical_specialty
Consensus Development Conferences as Topic
Rho(D) Immune Globulin
animal diseases
Alternative medicine
Isoantibodies
hemic and lymphatic diseases
medicine
Financial Support
Humans
Guideline development
Child
Intensive care medicine
Purpura, Thrombocytopenic, Idiopathic
Evidence-Based Medicine
Conflict of Interest
business.industry
Health Policy
Guideline
Immune thrombocytopenia
Management
Clinical Practice
Practice Guidelines as Topic
Splenectomy
business
Receptors, Thrombopoietin
Subjects
Details
- ISSN :
- 1555824X and 10628606
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- American Journal of Medical Quality
- Accession number :
- edsair.doi.dedup.....98bb260a0a6bb56a19c16999eea38a98