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Predicting Long-term Cognitive Dysfunction in Survivors of Critical Illness with Plasma Inflammatory Markers: a Retrospective Cohort Study
- Source :
- Molecular Neurobiology. 56:763-767
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Persistent inflammation in intensive care unit (ICU) survivors is associated with higher long-term mortality and poorer mobility. However, it is unknown if inflammatory markers are associated with other dysfunctions observed in survivors of critical illness. Thus, it was investigated if plasma levels of interleukin (IL)-6 and IL-10 at hospital discharge were associated with long-term functional and cognitive performance after ICU discharge. Adult patients admitted for > 48 h to a 20-bed mixed ICU in a University Hospital had blood collected within 48 h before hospital discharge to measure IL-6 and IL-10 levels. After a median time of 48 months, cognitive status was determined by the Mini-Mental State Examination (MMSE), and functional status was determined by the Barthel Index. Patients at the higher 25th percentile of both IL-6 and IL-10 had a worse long-term cognitive performance, but not worse functional status, even when adjusted for confounders after long-term follow-up. In conclusion, elevated circulating IL-6 and IL-10 concentrations at hospital discharge were associated with long-term cognitive dysfunction in ICU survivors.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Percentile
Neurology
Critical Illness
Neuroscience (miscellaneous)
law.invention
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
law
Internal medicine
medicine
Humans
Cognitive Dysfunction
Survivors
Effects of sleep deprivation on cognitive performance
Aged
Retrospective Studies
Inflammation
Interleukin-6
business.industry
Confounding
Retrospective cohort study
Cognition
Middle Aged
Intensive care unit
Interleukin-10
Intensive Care Units
030104 developmental biology
Critical illness
Female
business
Biomarkers
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15591182 and 08937648
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Molecular Neurobiology
- Accession number :
- edsair.doi.dedup.....989049ae8c38b5fea93b2c74429fd9da