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Telomere homeostasis in IUGR placentas – A review
- Source :
- Placenta. 39:21-23
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Telomeres are nucleoprotein structures located at the termini of chromosomes. They are essential for chromosome stability. Telomeres become shorter due to mitotic cycles and environmental factors. When telomeres are shortened and therefore dysfunctional, cellular senescence occurs and organ dysfunction might develop. During pregnancy, fetal growth restriction secondary to placental insufficiency has been linked to impaired telomere homeostasis in which telomeres are shorter, telomerase is decreased, and compensatory mechanisms of telomere capture are enhanced. These characteristics, along with increased signs of senescence, indicate telomere dysfunction in trophoblasts from placentas affected by intrauterine growth restriction (IUGR). This review summarizes the information currently available regarding telomere homeostasis in trophoblasts from human pregnancies affected by IUGR. Improved understanding of placental physiology might help in the development of treatment options for fetuses with IUGR.
- Subjects :
- 0301 basic medicine
Senescence
medicine.medical_specialty
Telomerase
Placenta
Intrauterine growth restriction
Placental insufficiency
Biology
03 medical and health sciences
0302 clinical medicine
Telomere Homeostasis
Pregnancy
Internal medicine
medicine
Animals
Humans
reproductive and urinary physiology
Fetal Growth Retardation
030219 obstetrics & reproductive medicine
Organ dysfunction
Obstetrics and Gynecology
Telomere
medicine.disease
Cell biology
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Reproductive Medicine
embryonic structures
Female
medicine.symptom
Developmental Biology
Subjects
Details
- ISSN :
- 01434004
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Placenta
- Accession number :
- edsair.doi.dedup.....988ff0542e263cb0e26cb1b598ad8721
- Full Text :
- https://doi.org/10.1016/j.placenta.2015.11.006