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Successful multidisciplinary treatment of Doege-Potter syndrome: hypoglycaemia caused by paraneoplastic IGF-2 production by a metastatic haemangiopericytoma
- Source :
- BMJ Case Rep
- Publication Year :
- 2023
-
Abstract
- Hypoglycaemia due to insulin-like growth factor (IGF)-2 secretion is a paraneoplastic complication of malignancy with significant morbidity that can often go unrecognised due to its uncommon presentation. We report on a case of a 51-year-old man with metastatic haemangiopericytoma presenting with refractory hypoglycaemia, requiring continuous dextrose 10% infusion while in hospital. IGF-2 levels were significantly elevated, in keeping with a rare entity associated with solitary fibrous tumours, known as Doege-Potter syndrome. The patient was managed using uncooked cornstarch in conjunction with debulking of the hepatic tumour burden with bland IR-guided transarterial embolisation, and eventual surgical resection to treat his non-islet cell tumour hypoglycaemia (NICTH). The case highlights this rare paraneoplastic phenomenon that should be included in the differential for hypoglycaemia, especially if a history of a solitary fibrous tumour is elicited. Our case is the first to document a successful approach to treating the hypoglycaemia using preoperative transarterial bland embolisation.
- Subjects :
- Male
medicine.medical_specialty
Paraneoplastic Syndromes
030209 endocrinology & metabolism
Case Report
Malignancy
Kidney
Congenital Abnormalities
03 medical and health sciences
0302 clinical medicine
Refractory
Surgical oncology
Insulin-Like Growth Factor II
medicine
Humans
Doege–Potter syndrome
medicine.diagnostic_test
business.industry
Interventional radiology
General Medicine
Hepatic tumour
Middle Aged
medicine.disease
Debulking
Hypoglycemia
Surgery
030220 oncology & carcinogenesis
Kidney Diseases
Complication
business
Hemangiopericytoma
Subjects
Details
- ISSN :
- 1757790X
- Volume :
- 14
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- BMJ case reports
- Accession number :
- edsair.doi.dedup.....9879cbfa7d9c6134f880a2b910d7c779