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Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease
- Source :
- American Journal of Physiology-Lung Cellular and Molecular Physiology. 288:L450-L459
- Publication Year :
- 2005
- Publisher :
- American Physiological Society, 2005.
-
Abstract
- Nitric oxide (NO) serves multiple functions in the developing lung, and pulmonary NO production is decreased in a baboon model of chronic lung disease (CLD) after premature birth at 125 days (d) gestation (term = 185d). To determine whether postnatal NO administration alters the genesis of CLD, the effects of inhaled NO (iNO, 5 ppm) were assessed in the baboon model over 14d. iNO caused a decrease in pulmonary artery pressure in the first 2d and a greater rate of spontaneous closure of the ductus arteriosus, and lung compliance was greater and expiratory resistance was improved during the first week. With iNO, postmortem pressure-volume curves were shifted upward, lung DNA content and cell proliferation were increased, and lung growth was preserved to equal that which occurs during the same period in utero. In addition, the excessive elastin deposition characteristic of CLD was normalized by iNO, and there was evidence of stimulation of secondary crest development. Thus, in the baboon model of CLD, iNO improves early pulmonary function and alters lung growth and extracellular matrix deposition. As such, NO biosynthetic pathway dysfunction may contribute to the pathogenesis of CLD.
- Subjects :
- Lung Diseases
Pulmonary and Respiratory Medicine
Pulmonary Circulation
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Physiology
Pulmonary Artery
Pulmonary compliance
Nitric Oxide
Pulmonary function testing
Physiology (medical)
Internal medicine
medicine.artery
Ductus arteriosus
biology.animal
Administration, Inhalation
Image Processing, Computer-Assisted
medicine
Animals
Respiratory system
Lung
biology
business.industry
Respiratory disease
Hemodynamics
Organ Size
Cell Biology
respiratory system
medicine.disease
Bronchodilator Agents
Elastin
respiratory tract diseases
Pulmonary Alveoli
medicine.anatomical_structure
Endocrinology
Animals, Newborn
Chronic Disease
Pulmonary artery
business
Papio
Baboon
Subjects
Details
- ISSN :
- 15221504 and 10400605
- Volume :
- 288
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Accession number :
- edsair.doi.dedup.....98791ee6565569eaa7532a984b1050c9