Intramural cyst originating from Luschka’s duct in the gall bladder: A case report

Highlights • A case of the intramural cyst of the gallbladder is rarely encountered. • The cyst derived from the Luschka duct, a specific histological element of the gallbladder, has not received much attention. • The gallbladder’s mural cyst, which is derived from the Luschka duct, is different from Rokitansky-Aschoff sinus origin.
Introduction and importance An intramural cyst is a rare lesion that develops in the wall of the gallbladder. Although the acquired cysts originate from the Rokitansky-Aschoff sinus (RAS), the congenital them, such as the duct of Luschka, are rare. Luschka's duct is a unique and specific tissue component that is histologically different from the inherent bile duct and without the communication to the lumen of the gallbladder. Case presentation A woman in her seventies underwent cholecystectomy for the treatment of repeated choledocholithiasis. Pathological examination of the resected specimen revealed multiple cysts in the subserosal tissue of the liver bed. The cysts were lined by cuboidal epithelium and surrounded by hypercellular fibrous tissue. Apart from the Luschka's ducts scattered around the cyst, no other components were observed. Immunohistochemically, the cystic epithelium was different from that of the gallbladder and phenotypically similar to that of the Luschka's duct. Discussion From histopathological and immunohistological findings, it was suggested that the cysts of the present case are not derived from RAS, which is the most common in the gallbladder, but from the Luschka’s duct. Conclusion We report an extremely rare case of intramural cysts that appear to have originated from the Luschka’s duct.