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Suppression of Tumor Growth in Strain 2 Guinea Pigs by Xenogeneic Antitumor Antibody
- Source :
- JNCI: Journal of the National Cancer Institute. 57:809-813
- Publication Year :
- 1976
- Publisher :
- Oxford University Press (OUP), 1976.
-
Abstract
- Line 10 hepatoma cells were incubated with antiserum specific against line 10 cells (RaL10) and then tested for growth in syngeneic Wright strain 2 guinea pigs. Palpable tumors appeared in only 11 of 23 animals inoculated id with 10(5) RaL10-treated tumor cells, compared with an incidence of 21 of 23 for nonimmune rabbit serum (NRS)-treated cells and 23 of 23 for cells treated with syngeneic guinea pig serum. Animals inoculated with RaL10-treated tumor cells did not develop systemic tumor immunity. The long-term survival of guinea pigs receiving RaL10-treated tumor cells iv was 6 of 12 with a dose of 10(5) cells and 8 of 11 with 10(4) cells. None of the animals receiving 10(4) or 10(5) control tumor cells treated with NRS survived. RaL10 antiserum was not toxic to line 10 tumor cells in vitro, but mediated tumor-specific cytolytic reactions in the presence of fresh guinea pig serum or on the addition of peritoneal exudate cells from nonimmunized syngeneic guinea pigs.
- Subjects :
- Male
Cancer Research
Pathology
medicine.medical_specialty
Carcinoma, Hepatocellular
Injections, Intradermal
Antibodies, Neoplasm
Guinea Pigs
Caviidae
Guinea pig
Antibody Specificity
Ascites
medicine
Animals
Ascitic Fluid
Transplantation, Homologous
Cells, Cultured
Antiserum
biology
Inoculation
Liver Neoplasms
Immunity
Neoplasms, Experimental
Cytotoxicity Tests, Immunologic
biology.organism_classification
medicine.disease
Molecular biology
In vitro
Cytolysis
Oncology
Injections, Intravenous
Immunotherapy
medicine.symptom
Liver cancer
Neoplasm Transplantation
Subjects
Details
- ISSN :
- 14602105 and 00278874
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- JNCI: Journal of the National Cancer Institute
- Accession number :
- edsair.doi.dedup.....983e3df0fca031e11197e322021bcd1b