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Single molecule based SNP detection using designed DNA carriers and solid-state nanopores
- Source :
- Chemical communications (Cambridge, England). 53(2)
- Publication Year :
- 2016
-
Abstract
- Single nucleotide polymorphisms (SNPs) play a crucial role as molecular markers in medical and diagnostic application. We demonstrate a nanopore based method for SNP detection at the single molecule level. Designed DNA carriers are used to distinguish DNA strands containing only one single base difference and follow strand displacement kinetics.
- Subjects :
- Models, Molecular
Solid-state
Single-nucleotide polymorphism
Nanotechnology
02 engineering and technology
Computational biology
Biosensing Techniques
010402 general chemistry
Molecular Inversion Probe
01 natural sciences
Polymorphism, Single Nucleotide
Catalysis
chemistry.chemical_compound
Nanopores
Materials Chemistry
SNP
Molecule
health care economics and organizations
Metals and Alloys
General Chemistry
DNA
021001 nanoscience & nanotechnology
3. Good health
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Nanopore
Kinetics
chemistry
Ceramics and Composites
Nucleic Acid Conformation
0210 nano-technology
DNA Probes
Subjects
Details
- ISSN :
- 1364548X
- Volume :
- 53
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Chemical communications (Cambridge, England)
- Accession number :
- edsair.doi.dedup.....983bdbf1199b6ef3289432917c63b8eb