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Haidinger’s brushes elicited at varying degrees of polarization rapidly and easily assesses total macular pigmentation
- Source :
- Temple, S, Roberts, N W & Misson, G P 2019, ' Haidinger’s brushes elicited at varying degrees of polarization rapidly and easily assesses total macular pigmentation ', Journal of the Optical Society of America A, vol. 36, no. 4, pp. B123-B131 . https://doi.org/10.1364/JOSAA.36.00B123
- Publication Year :
- 2019
-
Abstract
- Macular pigments (MPs), by absorbing potentially toxic short-wavelength (400–500 nm) visible light, provide protection against photo-chemical damage thought to be relevant in the pathogenesis of age-related macular degeneration (AMD). A method of screening for low levels of MPs could be part of a prevention strategy for helping people to delay the onset of AMD. We introduce a new method for assessing MP density that takes advantage of the polarization-dependent absorption of blue light by MPs, which results in the entoptic phenomenon called Haidinger’s brushes (HB). Subjects were asked to identify the direction of rotation of HB when presented with a circular stimulus illuminated with an even intensity of polarized white light in which the electric field vector was rotating either clockwise or anti-clockwise. By reducing the degree of polarization of the stimulus light, a threshold for perceiving HB (degree of polarization threshold) was determined and correlated (r 2 0.66) to macular pigment optical density assessed using dual-wavelength fundus autofluoresence. The speed and ease of measurement of degree of polarization threshold makes it well suited for large-scale screening of macular pigmentation.
- Subjects :
- Materials science
Time Factors
Rotation
genetic structures
Optical density
01 natural sciences
010309 optics
Macular Degeneration
Optics
0103 physical sciences
White light
medicine
Macular Pigment
Humans
Blue light
business.industry
Optical Devices
Macular degeneration
medicine.disease
Polarization (waves)
Atomic and Molecular Physics, and Optics
eye diseases
Electronic, Optical and Magnetic Materials
Scanning laser ophthalmoscopy
Degree of polarization
Computer Vision and Pattern Recognition
sense organs
business
Subjects
Details
- Language :
- English
- ISSN :
- 15208532
- Database :
- OpenAIRE
- Journal :
- Temple, S, Roberts, N W & Misson, G P 2019, ' Haidinger’s brushes elicited at varying degrees of polarization rapidly and easily assesses total macular pigmentation ', Journal of the Optical Society of America A, vol. 36, no. 4, pp. B123-B131 . https://doi.org/10.1364/JOSAA.36.00B123
- Accession number :
- edsair.doi.dedup.....98320e7c9f57e3d48fe195a8b1d745c8