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Antifungal drugs during pregnancy: an updated review
- Source :
- Journal of Antimicrobial Chemotherapy, Journal of Antimicrobial Chemotherapy, 2014, 70 (1), pp.14-22. ⟨10.1093/jac/dku355⟩, Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2014, 70 (1), pp.14-22. ⟨10.1093/jac/dku355⟩
- Publication Year :
- 2014
-
Abstract
- International audience; Antifungal prescription remains a challenge in pregnant women because of uncertainties regarding fetal toxicity and altered maternal pharmacokinetic parameters that may affect efficacy or increase maternal and fetal toxicity. We present updated data reviewing the available knowledge and current recommendations regarding antifungal prescription in pregnancy. Amphotericin B remains the first-choice parenteral drug in spite of its well-established toxicity. Topical drugs are used throughout pregnancy because of limited absorption. Recent data have clarified the teratogenic effect of high-dose fluconazole during the first trimester and provided reassuring cumulative data regarding its use at a single low dose in this key period. Recent data have also provided additional safety data on itraconazole and lipidic derivatives of amphotericin B. Regarding newer antifungal drugs, including posaconazole and echinocandins, clinical data are critically needed before considering prescription in pregnancy.
- Subjects :
- Antifungal Agents
MESH: Administration, Intravenous
[SDV]Life Sciences [q-bio]
Antifungal drugs
Administration, Topical
Pharmacology
MESH: Pregnancy
0302 clinical medicine
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Pregnancy
Medicine
Pharmacology (medical)
030212 general & internal medicine
Pregnancy Complications, Infectious
Fluconazole
[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
030219 obstetrics & reproductive medicine
MESH: Administration, Topical
3. Good health
fetus
MESH: Teratogens
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Infectious Diseases
Teratogens
fungal infections
MESH: Fluconazole
Liposomal amphotericin
Administration, Intravenous
Female
Itraconazole
Microbiology (medical)
placenta
03 medical and health sciences
Animal data
MESH: Anti-Infective Agents, Local
MESH: Mycoses
Amphotericin B
MESH: Amphotericin B
Humans
MESH: Pregnancy Complications, Infectious
MESH: Humans
business.industry
MESH: Antifungal Agents
bacterial infections and mycoses
antifungal therapy
Mycoses
Anti-Infective Agents, Local
business
MESH: Female
MESH: Itraconazole
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Classics
Subjects
Details
- ISSN :
- 14602091 and 03057453
- Volume :
- 70
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Journal of antimicrobial chemotherapy
- Accession number :
- edsair.doi.dedup.....98276140eef493ae36719b3593ac8fca