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Cocaine-induced behavioral sensitization is greater in adolescent than in adult mice and heightens cocaine-induced conditioned place preference in adolescents
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Adolescents are more sensitive than adults to the neural and behavioral effects of psychostimulants, and exhibit greater vulnerability to drug abuse, dependence or relapse into these conditions. We have reported that cocaine pretreatment during adolescence promotes the expression of behavioral sensitization to a greater extent than when the pretreatment occurs at adulthood. Behavioral sensitization has been associated to the transition from drug use to addiction and is postulated to indicate heightened sensitivity to the appetitive motivational effects of drugs. The relationship between behavioral sensitization and conventional measures of drug reward, such as conditioned place preference (CPP), has yet to be thoroughly investigated, and little is known about age-related differences in this phenomenon. The present study tested cocaine-induced CPP in adolescent and adult mice exposed to cocaine (or vehicle) pretreatment, either in an intermittent or "binge" (i.e., heavy cocaine use on a single occasion, which increases the likelihood of experiencing cocaine-related problems) fashion. Cocaine administration induced behavioral sensitization to a greater extent in adolescent than in adult mice. Cocaine-induced CPP was fairly similar in vehicle pretreated adolescent and adult mice, yet greater in adolescent vs. adults after cocaine-induced sensitization. The results confirmed the higher sensitivity of adolescent mice to cocaine-induced behavioral sensitization and suggest its association with greater sensitivity to cocaine's rewarding effects.
- Subjects :
- Male
medicine.medical_specialty
media_common.quotation_subject
Conditioning, Classical
Clinical Biochemistry
Drug Evaluation, Preclinical
Toxicology
Biochemistry
Behavioral sensitization
Cocaine-Related Disorders
Mice
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Cocaine
Reward
Internal medicine
medicine
In vehicle
Animals
Biological Psychiatry
Sensitization
media_common
Pharmacology
Analysis of Variance
Behavior, Animal
business.industry
Addiction
medicine.disease
Conditioned place preference
030227 psychiatry
Substance abuse
Endocrinology
medicine.anatomical_structure
Cocaine use
Central Nervous System Stimulants
CAMUNDONGOS
Saline Solution
business
Locomotion
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00913057
- Volume :
- 181
- Database :
- OpenAIRE
- Journal :
- Pharmacology Biochemistry and Behavior
- Accession number :
- edsair.doi.dedup.....9802eaa85edff1cf60e951273bdb0ccd