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DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
- Source :
- PLoS Genetics (print), 10(4). Public Library of Science, Recercat. Dipósit de la Recerca de Catalunya, instname, Osorio, A, Milne, R L, Kuchenbaecker, K, Vaclová, T, Pita, G, Alonso, R, Peterlongo, P, Blanco, I, de la Hoya, M, Duran, M, Díez, O, Ramón Y Cajal, T, Konstantopoulou, I, Martínez-Bouzas, C, Andrés Conejero, R, Soucy, P, McGuffog, L, Barrowdale, D, Lee, A, Swe-Brca, Arver, B, Rantala, J, Loman, N, Ehrencrona, H, Olopade, O I, Beattie, M S, Domchek, S M, Nathanson, K, Rebbeck, T R, Arun, B K, Karlan, B Y, Walsh, C, Lester, J, John, E M, Whittemore, A S, Daly, M B, Southey, M, Hopper, J, Terry, M B, Buys, S S, Janavicius, R, Dorfling, C M, van Rensburg, E J, Steele, L, Neuhausen, S L, Ding, Y C, Hansen, T V O, Jønson, L, Ejlertsen, B, Gerdes, A-M, Infante, M, Herráez, B, Moreno, L T, Weitzel, J N, Herzog, J, Weeman, K, Manoukian, S, Peissel, B, Zaffaroni, D, Scuvera, G, Bonanni, B, Mariette, F, Volorio, S, Viel, A, Varesco, L, Papi, L, Ottini, L, Tibiletti, M G, Radice, P, Yannoukakos, D, Garber, J, Ellis, S, Frost, D, Platte, R, Fineberg, E, Evans, G, Lalloo, F, Izatt, L, Eeles, R, Adlard, J, Davidson, R, Cole, T, Eccles, D, Cook, J, Hodgson, S, Brewer, C, Tischkowitz, M, Douglas, F, Porteous, M, Side, L, Walker, L, Morrison, P, Donaldson, A, Kennedy, J, Foo, C, Godwin, A K, Schmutzler, R K, Wappenschmidt, B, Rhiem, K, Engel, C, Meindl, A, Ditsch, N, Arnold, N, Plendl, H J, Niederacher, D, Sutter, C, Wang-Gohrke, S, Steinemann, D, Preisler-Adams, S, Kast, K, Varon-Mateeva, R, Gehrig, A, Stoppa-Lyonnet, D, Sinilnikova, O M, Mazoyer, S, Damiola, F, Poppe, B, Claes, K, Piedmonte, M, Tucker, K, Backes, F, Rodríguez, G, Brewster, W, Wakeley, K, Rutherford, T, Caldés, T, Nevanlinna, H, Aittomäki, K, Rookus, M A, van Os, T A M, van der Kolk, L, de Lange, J L, Meijers-Heijboer, H E J, van der Hout, A H, van Asperen, C J, Gómez Garcia, E B, Hoogerbrugge, N, Collée, J M, van Deurzen, C H M, van der Luijt, R B, Devilee, P, Hebon, Olah, E, Lázaro, C, Teulé, A, Menéndez, M, Jakubowska, A, Cybulski, C, Gronwald, J, Lubinski, J, Durda, K, Jaworska-Bieniek, K, Johannsson, O T, Maugard, C, Montagna, M, Tognazzo, S, Teixeira, M R, Healey, S, Investigators, K, Olswold, C, Guidugli, L, Lindor, N, Slager, S, Szabo, C I, Vijai, J, Robson, M, Kauff, N, Zhang, L, Rau-Murthy, R, Fink-Retter, A, Singer, C F, Rappaport, C, Geschwantler Kaulich, D, Pfeiler, G, Tea, M-K, Berger, A, Phelan, C M, Greene, M H, Mai, P L, Lejbkowicz, F, Andrulis, I, Mulligan, A M, Glendon, G, Toland, A E, Bojesen, A, Pedersen, I S, Sunde, L, Thomassen, M, Kruse, T A, Jensen, U B, Friedman, E, Laitman, Y, Shimon, S P, Simard, J, Easton, D F, Offit, K, Couch, F J, Chenevix-Trench, G, Antoniou, A C & Benitez, J 2014, ' DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers ', P L o S Genetics, vol. 10, no. 4, e1004256 . https://doi.org/10.1371/journal.pgen.1004256, UVaDOC: Repositorio Documental de la Universidad de Valladolid, Universidad de Valladolid, PLoS Genetics; 10(4), no e1004256 (2014), PLoS Genetics, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, Dipòsit Digital de la UB, Universidad de Barcelona, Repisalud, Instituto de Salud Carlos III (ISCIII), Osorio, A, Milne, R L, Kuchenbaecker, K, Vaclová, T, Pita, G, Alonso, R, Peterlongo, P, Blanco, I, de la Hoya, M, Duran, M, Díez, O, Ramón Y Cajal, T, Konstantopoulou, I, Martínez-Bouzas, C, Andrés Conejero, R, Soucy, P, McGuffog, L, Barrowdale, D, Lee, A, Swe-Brca, Arver, B, Rantala, J, Loman, N, Ehrencrona, H, Olopade, O I, Beattie, M S, Domchek, S M, Nathanson, K, Rebbeck, T R, Arun, B K, Karlan, B Y, Walsh, C, Lester, J, John, E M, Whittemore, A S, Daly, M B, Southey, M, Hopper, J, Terry, M B, Buys, S S, Janavicius, R, Dorfling, C M, van Rensburg, E J, Steele, L, Neuhausen, S L, Ding, Y C, Hansen, T V O, Jønson, L, Ejlertsen, B, Gerdes, A-M, Infante, M, Herráez, B, Moreno, L T, Weitzel, J N, Herzog, J, Weeman, K, Manoukian, S, Peissel, B, Zaffaroni, D, Scuvera, G, Bonanni, B, Mariette, F, Volorio, S, Viel, A, Varesco, L, Papi, L, Ottini, L, Tibiletti, M G, Radice, P, Yannoukakos, D, Garber, J, Ellis, S, Frost, D, Platte, R, Fineberg, E, Evans, G, Lalloo, F, Izatt, L, Eeles, R, Adlard, J, Davidson, R, Cole, T, Eccles, D, Cook, J, Hodgson, S, Brewer, C, Tischkowitz, M, Douglas, F, Porteous, M, Side, L, Walker, L, Morrison, P, Donaldson, A, Kennedy, J, Foo, C, Godwin, A K, Schmutzler, R K, Wappenschmidt, B, Rhiem, K, Engel, C, Meindl, A, Ditsch, N, Arnold, N, Plendl, H J, Niederacher, D, Sutter, C, Wang-Gohrke, S, Steinemann, D, Preisler-Adams, S, Kast, K, Varon-Mateeva, R, Gehrig, A, Stoppa-Lyonnet, D, Sinilnikova, O M, Mazoyer, S, Damiola, F, Poppe, B, Claes, K, Piedmonte, M, Tucker, K, Backes, F, Rodríguez, G, Brewster, W, Wakeley, K, Rutherford, T, Caldés, T, Nevanlinna, H, Aittomäki, K, Rookus, M A, van Os, T A M, van der Kolk, L, de Lange, J L, Meijers-Heijboer, H E J, van der Hout, A H, van Asperen, C J, Gómez Garcia, E B, Hoogerbrugge, N, Collée, J M, van Deurzen, C H M, van der Luijt, R B, Devilee, P, Hebon, Olah, E, Lázaro, C, Teulé, A, Menéndez, M, Jakubowska, A, Cybulski, C, Gronwald, J, Lubinski, J, Durda, K, Jaworska-Bieniek, K, Johannsson, O T, Maugard, C, Montagna, M, Tognazzo, S, Teixeira, M R, Healey, S, Investigators, K, Olswold, C, Guidugli, L, Lindor, N, Slager, S, Szabo, C I, Vijai, J, Robson, M, Kauff, N, Zhang, L, Rau-Murthy, R, Fink-Retter, A, Singer, C F, Rappaport, C, Geschwantler Kaulich, D, Pfeiler, G, Tea, M-K, Berger, A, Phelan, C M, Greene, M H, Mai, P L, Lejbkowicz, F, Andrulis, I, Mulligan, A M, Glendon, G, Toland, A E, Bojesen, A, Pedersen, I S, Sunde, L, Thomassen, M, Kruse, T A, Jensen, U B, Friedman, E, Laitman, Y, Shimon, S P, Simard, J, Easton, D F, Offit, K, Couch, F J, Chenevix-Trench, G, Antoniou, A C & Benitez, J 2014, ' DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers ', PLoS genetics, vol. 10, no. 4, pp. e1004256 . https://doi.org/10.1371/journal.pgen.1004256, UVaDOC. Repositorio Documental de la Universidad de Valladolid, Osorio, A, Milne, R L, Kuchenbaecker, K, Vaclova, T, Pita, G, Alonso, R, Peterlongo, P, Blanco, I, de la Hoya, M, Duran, M, Diez, O, Cajal, T R Y, Konstantopoulou, I, Martinez-Bouzas, C, Conejero, R A, Soucy, P, McGuffog, L, Barrowdale, D, van der Lee, A, Arver, B, Rantala, J, Loman, N, Ehrencrona, H, Olopade, O I, Beattie, M S, Domchek, S M, Nathanson, K, Rebbeck, T R, Arun, B K, Karlan, B Y, Walsh, C, Lester, J, John, E M, Whittemore, A S, Daly, M B, Southey, M, Hopper, J, Terry, M B, Buys, S S, Janavicius, R, Dorfling, C M, van Rensburg, E J, Steele, L, Neuhausen, S L, Ding, Y C, Hansen, T V O, Jonson, L, Ejlertsen, B, Gerdes, A M, Infante, M, Herraez, B, Moreno, L T, Weitzel, J N, Herzog, J, Weeman, K, Manoukian, S, Peissel, B, Zaffaroni, D, Scuvera, G, Bonanni, B, Mariette, F, Volorio, S, Viel, A, Varesco, L, Papi, L, Ottini, L, Tibiletti, M G, Radice, P, Yannoukakos, D, Garber, J, Ellis, S, Frost, D, Platte, R, Fineberg, E, Evans, G, Lalloo, F, Izatt, L, Eeles, R, Adlard, J, Davidson, R, Cole, T, Eccles, D, Cook, J, Hodgson, S, Brewer, C, Tischkowitz, M, Douglas, F, Porteous, M, Side, L, Walker, L, Morrison, P, Donaldson, A, Kennedy, J, Foo, C, Godwin, A K, Schmutzler, R K, Wappenschmidt, B, Rhiem, K, Engel, C, Meijers-Heijboer, E J, Antoniou, A C & Benitez, J 2014, ' DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers ', PLoS Genetics, vol. 10, no. 4, e1004256 . https://doi.org/10.1371/journal.pgen.1004256, Osorio, A, Milne, R L, Kuchenbaecker, K, Vaclová, T, Pita, G, Alonso, R, Peterlongo, P, Blanco, I, de la Hoya, M, Duran, M, Díez, O, Ramón Y Cajal, T, Konstantopoulou, I, Martínez-Bouzas, C, Andrés Conejero, R, Soucy, P, McGuffog, L, Barrowdale, D, Lee, A, Swe-Brca, Arver, B, Rantala, J, Loman, N, Ehrencrona, H, Olopade, O I, Beattie, M S, Domchek, S M, Nathanson, K, Rebbeck, T R, Arun, B K, Karlan, B Y, Walsh, C, Lester, J, John, E M, Whittemore, A S, Daly, M B, Southey, M, Hopper, J, Terry, M B, Buys, S S, Janavicius, R, Dorfling, C M, van Rensburg, E J, Steele, L, Neuhausen, S L, Ding, Y C, Hansen, T V O, Jønson, L, Ejlertsen, B, Gerdes, A-M, Infante, M, Herráez, B, Moreno, L T, Weitzel, J N, Herzog, J, Weeman, K, Manoukian, S, Peissel, B, Zaffaroni, D, Scuvera, G, Bonanni, B, Mariette, F, Volorio, S, Viel, A, Varesco, L, Papi, L, Ottini, L, Tibiletti, M G, Radice, P, Yannoukakos, D, Garber, J, Ellis, S, Frost, D, Platte, R, Fineberg, E, Evans, G, Lalloo, F, Izatt, L, Eeles, R, Adlard, J, Davidson, R, Cole, T, Eccles, D, Cook, J, Hodgson, S, Brewer, C, Tischkowitz, M, Douglas, F, Porteous, M, Side, L, Walker, L, Morrison, P, Donaldson, A, Kennedy, J, Foo, C, Godwin, A K, Schmutzler, R K, Wappenschmidt, B, Rhiem, K, Engel, C, Meindl, A, Ditsch, N, Arnold, N, Plendl, H J, Niederacher, D, Sutter, C, Wang-Gohrke, S, Steinemann, D, Preisler-Adams, S, Kast, K, Varon-Mateeva, R, Gehrig, A, Stoppa-Lyonnet, D, Sinilnikova, O M, Mazoyer, S, Damiola, F, Poppe, B, Claes, K, Piedmonte, M, Tucker, K, Backes, F, Rodríguez, G, Brewster, W, Wakeley, K, Rutherford, T, Caldés, T, Nevanlinna, H, Aittomäki, K, Rookus, M A, van Os, T A M, van der Kolk, L, de Lange, J L, Meijers-Heijboer, H E J, van der Hout, A H, van Asperen, C J, Gómez Garcia, E B, Hoogerbrugge, N, Collée, J M, van Deurzen, C H M, van der Luijt, R B, Devilee, P, Hebon, Olah, E, Lázaro, C, Teulé, A, Menéndez, M, Jakubowska, A, Cybulski, C, Gronwald, J, Lubinski, J, Durda, K, Jaworska-Bieniek, K, Johannsson, O T, Maugard, C, Montagna, M, Tognazzo, S, Teixeira, M R, Healey, S, Investigators, K, Olswold, C, Guidugli, L, Lindor, N, Slager, S, Szabo, C I, Vijai, J, Robson, M, Kauff, N, Zhang, L, Rau-Murthy, R, Fink-Retter, A, Singer, C F, Rappaport, C, Geschwantler Kaulich, D, Pfeiler, G, Tea, M-K, Berger, A, Phelan, C M, Greene, M H, Mai, P L, Lejbkowicz, F, Andrulis, I, Mulligan, A M, Glendon, G, Toland, A E, Bojesen, A, Pedersen, I S, Sunde, L, Thomassen, M, Kruse, T A, Jensen, U B, Friedman, E, Laitman, Y, Shimon, S P, Simard, J, Easton, D F, Offit, K, Couch, F J, Chenevix-Trench, G, Antoniou, A C & Benitez, J 2014, ' DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers ', P L o S Genetics, vol. 10, no. 4, pp. e1004256 . https://doi.org/10.1371/journal.pgen.1004256, PLoS genetics, 10(4). Public Library of Science, PLoS Genetics; Vol 10, Plos Genetics, 10, e1004256, PLoS Genetics, 10(4), PLoS Genetics, Vol 10, Iss 4, p e1004256 (2014), Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, PLoS genetics, 10(4):e1004256. PUBLIC LIBRARY SCIENCE, PLoS Genetics, 10(4):e1004256. Public Library of Science, Plos Genetics, 10, 4, pp. e1004256, PLOS GENETICS
- Publication Year :
- 2014
-
Abstract
- Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of synthetic lethality that exists between one of the components of the BER pathway, PARP1 (poly ADP ribose polymerase), and both BRCA1 and BRCA2. In the present study, we have performed a comprehensive analysis of 18 genes involved in BER using a tagging SNP approach in a large series of BRCA1 and BRCA2 mutation carriers. 144 SNPs were analyzed in a two stage study involving 23,463 carriers from the CIMBA consortium (the Consortium of Investigators of Modifiers of BRCA1 and BRCA2). Eleven SNPs showed evidence of association with breast and/or ovarian cancer at p<br />Author Summary Women harboring a germ-line mutation in the BRCA1 or BRCA2 genes have a high lifetime risk to develop breast and/or ovarian cancer. However, not all carriers develop cancer and high variability exists regarding age of onset of the disease and type of tumor. One of the causes of this variability lies in other genetic factors that modulate the phenotype, the so-called modifier genes. Identification of these genes might have important implications for risk assessment and decision making regarding prevention of the disease. Given that BRCA1 and BRCA2 participate in the repair of DNA double strand breaks, here we have investigated whether variations, Single Nucleotide Polymorphisms (SNPs), in genes participating in other DNA repair pathway may be associated with cancer risk in BRCA carriers. We have selected the Base Excision Repair pathway because BRCA defective cells are extremely sensitive to the inhibition of one of its components, PARP1. Thanks to a large international collaborative effort, we have been able to identify at least two SNPs that are associated with increased cancer risk in BRCA1 and BRCA2 mutation carriers respectively. These findings could have implications not only for risk assessment, but also for treatment of BRCA1/2 mutation carriers with PARP inhibitors.
- Subjects :
- Cancer Research
24 Ciencias de la Vida
DNA Repair
endocrine system diseases
ADN
Càncer d'ovari
Synthetic lethality
BRCA1 Protein/genetics
DNA Glycosylases
0302 clinical medicine
DNA Glycosylases/genetics
Brjóstakrabbamein
Genotype
Medicine and Health Sciences
Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14]
Glicosilasas
INVESTIGATORS
skin and connective tissue diseases
OGG1
Genetics (clinical)
Genetics
DAMAGE
Aged, 80 and over
Ovarian Neoplasms
0303 health sciences
BRCA1 Protein
SINGLE-NUCLEOTIDE POLYMORPHISMS
COMMON VARIANTS
Base excision repair
Middle Aged
BRCA2 Protein
3. Good health
030220 oncology & carcinogenesis
NEIL2
Female
Medical Genetics
Research Article
BRCA1
BRCA2
Adult
Risk
Ovarian Neoplasms/genetics
lcsh:QH426-470
Adolescent
DNA repair
education
Single-nucleotide polymorphism
Breast Neoplasms
DNA Repair/genetics
Biology
Breast Neoplasms/genetics
Polymorphism, Single Nucleotide
OVARIAN-CANCER
03 medical and health sciences
Polymorphism, Single Nucleotide/genetics
SDG 3 - Good Health and Well-being
Ovarian cancer
Cancer Genetics
BREAST-CANCER
Humans
Genetic Predisposition to Disease
ddc:610
Molecular Biology
Gene
Ecology, Evolution, Behavior and Systematics
030304 developmental biology
Aged
BRCA2 Protein/genetics
CONSORTIUM
Biology and Life Sciences
Arfgengi
lcsh:Genetics
DNA glycosylase
Cancer research
3111 Biomedicine
GENETIC MODIFIERS
Genètica
Subjects
Details
- Language :
- English
- ISSN :
- 15537390 and 15537404
- Database :
- OpenAIRE
- Journal :
- PLoS Genetics (print), 10(4). Public Library of Science, Recercat. Dipósit de la Recerca de Catalunya, instname, Osorio, A, Milne, R L, Kuchenbaecker, K, Vaclová, T, Pita, G, Alonso, R, Peterlongo, P, Blanco, I, de la Hoya, M, Duran, M, Díez, O, Ramón Y Cajal, T, Konstantopoulou, I, Martínez-Bouzas, C, Andrés Conejero, R, Soucy, P, McGuffog, L, Barrowdale, D, Lee, A, Swe-Brca, Arver, B, Rantala, J, Loman, N, Ehrencrona, H, Olopade, O I, Beattie, M S, Domchek, S M, Nathanson, K, Rebbeck, T R, Arun, B K, Karlan, B Y, Walsh, C, Lester, J, John, E M, Whittemore, A S, Daly, M B, Southey, M, Hopper, J, Terry, M B, Buys, S S, Janavicius, R, Dorfling, C M, van Rensburg, E J, Steele, L, Neuhausen, S L, Ding, Y C, Hansen, T V O, Jønson, L, Ejlertsen, B, Gerdes, A-M, Infante, M, Herráez, B, Moreno, L T, Weitzel, J N, Herzog, J, Weeman, K, Manoukian, S, Peissel, B, Zaffaroni, D, Scuvera, G, Bonanni, B, Mariette, F, Volorio, S, Viel, A, Varesco, L, Papi, L, Ottini, L, Tibiletti, M G, Radice, P, Yannoukakos, D, Garber, J, Ellis, S, Frost, D, Platte, R, Fineberg, E, Evans, G, Lalloo, F, Izatt, L, Eeles, R, Adlard, J, Davidson, R, Cole, T, Eccles, D, Cook, J, Hodgson, S, Brewer, C, Tischkowitz, M, Douglas, F, Porteous, M, Side, L, Walker, L, Morrison, P, Donaldson, A, Kennedy, J, Foo, C, Godwin, A K, Schmutzler, R K, Wappenschmidt, B, Rhiem, K, Engel, C, Meindl, A, Ditsch, N, Arnold, N, Plendl, H J, Niederacher, D, Sutter, C, Wang-Gohrke, S, Steinemann, D, Preisler-Adams, S, Kast, K, Varon-Mateeva, R, Gehrig, A, Stoppa-Lyonnet, D, Sinilnikova, O M, Mazoyer, S, Damiola, F, Poppe, B, Claes, K, Piedmonte, M, Tucker, K, Backes, F, Rodríguez, G, Brewster, W, Wakeley, K, Rutherford, T, Caldés, T, Nevanlinna, H, Aittomäki, K, Rookus, M A, van Os, T A M, van der Kolk, L, de Lange, J L, Meijers-Heijboer, H E J, van der Hout, A H, van Asperen, C J, Gómez Garcia, E B, Hoogerbrugge, N, Collée, J M, van Deurzen, C H M, van der Luijt, R B, Devilee, P, Hebon, Olah, E, Lázaro, C, Teulé, A, Menéndez, M, Jakubowska, A, Cybulski, C, Gronwald, J, Lubinski, J, Durda, K, Jaworska-Bieniek, K, Johannsson, O T, Maugard, C, Montagna, M, Tognazzo, S, Teixeira, M R, Healey, S, Investigators, K, Olswold, C, Guidugli, L, Lindor, N, Slager, S, Szabo, C I, Vijai, J, Robson, M, Kauff, N, Zhang, L, Rau-Murthy, R, Fink-Retter, A, Singer, C F, Rappaport, C, Geschwantler Kaulich, D, Pfeiler, G, Tea, M-K, Berger, A, Phelan, C M, Greene, M H, Mai, P L, Lejbkowicz, F, Andrulis, I, Mulligan, A M, Glendon, G, Toland, A E, Bojesen, A, Pedersen, I S, Sunde, L, Thomassen, M, Kruse, T A, Jensen, U B, Friedman, E, Laitman, Y, Shimon, S P, Simard, J, Easton, D F, Offit, K, Couch, F J, Chenevix-Trench, G, Antoniou, A C & Benitez, J 2014, ' DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers ', P L o S Genetics, vol. 10, no. 4, e1004256 . https://doi.org/10.1371/journal.pgen.1004256, UVaDOC: Repositorio Documental de la Universidad de Valladolid, Universidad de Valladolid, PLoS Genetics; 10(4), no e1004256 (2014), PLoS Genetics, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, Dipòsit Digital de la UB, Universidad de Barcelona, Repisalud, Instituto de Salud Carlos III (ISCIII), Osorio, A, Milne, R L, Kuchenbaecker, K, Vaclová, T, Pita, G, Alonso, R, Peterlongo, P, Blanco, I, de la Hoya, M, Duran, M, Díez, O, Ramón Y Cajal, T, Konstantopoulou, I, Martínez-Bouzas, C, Andrés Conejero, R, Soucy, P, McGuffog, L, Barrowdale, D, Lee, A, Swe-Brca, Arver, B, Rantala, J, Loman, N, Ehrencrona, H, Olopade, O I, Beattie, M S, Domchek, S M, Nathanson, K, Rebbeck, T R, Arun, B K, Karlan, B Y, Walsh, C, Lester, J, John, E M, Whittemore, A S, Daly, M B, Southey, M, Hopper, J, Terry, M B, Buys, S S, Janavicius, R, Dorfling, C M, van Rensburg, E J, Steele, L, Neuhausen, S L, Ding, Y C, Hansen, T V O, Jønson, L, Ejlertsen, B, Gerdes, A-M, Infante, M, Herráez, B, Moreno, L T, Weitzel, J N, Herzog, J, Weeman, K, Manoukian, S, Peissel, B, Zaffaroni, D, Scuvera, G, Bonanni, B, Mariette, F, Volorio, S, Viel, A, Varesco, L, Papi, L, Ottini, L, Tibiletti, M G, Radice, P, Yannoukakos, D, Garber, J, Ellis, S, Frost, D, Platte, R, Fineberg, E, Evans, G, Lalloo, F, Izatt, L, Eeles, R, Adlard, J, Davidson, R, Cole, T, Eccles, D, Cook, J, Hodgson, S, Brewer, C, Tischkowitz, M, Douglas, F, Porteous, M, Side, L, Walker, L, Morrison, P, Donaldson, A, Kennedy, J, Foo, C, Godwin, A K, Schmutzler, R K, Wappenschmidt, B, Rhiem, K, Engel, C, Meindl, A, Ditsch, N, Arnold, N, Plendl, H J, Niederacher, D, Sutter, C, Wang-Gohrke, S, Steinemann, D, Preisler-Adams, S, Kast, K, Varon-Mateeva, R, Gehrig, A, Stoppa-Lyonnet, D, Sinilnikova, O M, Mazoyer, S, Damiola, F, Poppe, B, Claes, K, Piedmonte, M, Tucker, K, Backes, F, Rodríguez, G, Brewster, W, Wakeley, K, Rutherford, T, Caldés, T, Nevanlinna, H, Aittomäki, K, Rookus, M A, van Os, T A M, van der Kolk, L, de Lange, J L, Meijers-Heijboer, H E J, van der Hout, A H, van Asperen, C J, Gómez Garcia, E B, Hoogerbrugge, N, Collée, J M, van Deurzen, C H M, van der Luijt, R B, Devilee, P, Hebon, Olah, E, Lázaro, C, Teulé, A, Menéndez, M, Jakubowska, A, Cybulski, C, Gronwald, J, Lubinski, J, Durda, K, Jaworska-Bieniek, K, Johannsson, O T, Maugard, C, Montagna, M, Tognazzo, S, Teixeira, M R, Healey, S, Investigators, K, Olswold, C, Guidugli, L, Lindor, N, Slager, S, Szabo, C I, Vijai, J, Robson, M, Kauff, N, Zhang, L, Rau-Murthy, R, Fink-Retter, A, Singer, C F, Rappaport, C, Geschwantler Kaulich, D, Pfeiler, G, Tea, M-K, Berger, A, Phelan, C M, Greene, M H, Mai, P L, Lejbkowicz, F, Andrulis, I, Mulligan, A M, Glendon, G, Toland, A E, Bojesen, A, Pedersen, I S, Sunde, L, Thomassen, M, Kruse, T A, Jensen, U B, Friedman, E, Laitman, Y, Shimon, S P, Simard, J, Easton, D F, Offit, K, Couch, F J, Chenevix-Trench, G, Antoniou, A C & Benitez, J 2014, ' DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers ', PLoS genetics, vol. 10, no. 4, pp. e1004256 . https://doi.org/10.1371/journal.pgen.1004256, UVaDOC. Repositorio Documental de la Universidad de Valladolid, Osorio, A, Milne, R L, Kuchenbaecker, K, Vaclova, T, Pita, G, Alonso, R, Peterlongo, P, Blanco, I, de la Hoya, M, Duran, M, Diez, O, Cajal, T R Y, Konstantopoulou, I, Martinez-Bouzas, C, Conejero, R A, Soucy, P, McGuffog, L, Barrowdale, D, van der Lee, A, Arver, B, Rantala, J, Loman, N, Ehrencrona, H, Olopade, O I, Beattie, M S, Domchek, S M, Nathanson, K, Rebbeck, T R, Arun, B K, Karlan, B Y, Walsh, C, Lester, J, John, E M, Whittemore, A S, Daly, M B, Southey, M, Hopper, J, Terry, M B, Buys, S S, Janavicius, R, Dorfling, C M, van Rensburg, E J, Steele, L, Neuhausen, S L, Ding, Y C, Hansen, T V O, Jonson, L, Ejlertsen, B, Gerdes, A M, Infante, M, Herraez, B, Moreno, L T, Weitzel, J N, Herzog, J, Weeman, K, Manoukian, S, Peissel, B, Zaffaroni, D, Scuvera, G, Bonanni, B, Mariette, F, Volorio, S, Viel, A, Varesco, L, Papi, L, Ottini, L, Tibiletti, M G, Radice, P, Yannoukakos, D, Garber, J, Ellis, S, Frost, D, Platte, R, Fineberg, E, Evans, G, Lalloo, F, Izatt, L, Eeles, R, Adlard, J, Davidson, R, Cole, T, Eccles, D, Cook, J, Hodgson, S, Brewer, C, Tischkowitz, M, Douglas, F, Porteous, M, Side, L, Walker, L, Morrison, P, Donaldson, A, Kennedy, J, Foo, C, Godwin, A K, Schmutzler, R K, Wappenschmidt, B, Rhiem, K, Engel, C, Meijers-Heijboer, E J, Antoniou, A C & Benitez, J 2014, ' DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers ', PLoS Genetics, vol. 10, no. 4, e1004256 . https://doi.org/10.1371/journal.pgen.1004256, Osorio, A, Milne, R L, Kuchenbaecker, K, Vaclová, T, Pita, G, Alonso, R, Peterlongo, P, Blanco, I, de la Hoya, M, Duran, M, Díez, O, Ramón Y Cajal, T, Konstantopoulou, I, Martínez-Bouzas, C, Andrés Conejero, R, Soucy, P, McGuffog, L, Barrowdale, D, Lee, A, Swe-Brca, Arver, B, Rantala, J, Loman, N, Ehrencrona, H, Olopade, O I, Beattie, M S, Domchek, S M, Nathanson, K, Rebbeck, T R, Arun, B K, Karlan, B Y, Walsh, C, Lester, J, John, E M, Whittemore, A S, Daly, M B, Southey, M, Hopper, J, Terry, M B, Buys, S S, Janavicius, R, Dorfling, C M, van Rensburg, E J, Steele, L, Neuhausen, S L, Ding, Y C, Hansen, T V O, Jønson, L, Ejlertsen, B, Gerdes, A-M, Infante, M, Herráez, B, Moreno, L T, Weitzel, J N, Herzog, J, Weeman, K, Manoukian, S, Peissel, B, Zaffaroni, D, Scuvera, G, Bonanni, B, Mariette, F, Volorio, S, Viel, A, Varesco, L, Papi, L, Ottini, L, Tibiletti, M G, Radice, P, Yannoukakos, D, Garber, J, Ellis, S, Frost, D, Platte, R, Fineberg, E, Evans, G, Lalloo, F, Izatt, L, Eeles, R, Adlard, J, Davidson, R, Cole, T, Eccles, D, Cook, J, Hodgson, S, Brewer, C, Tischkowitz, M, Douglas, F, Porteous, M, Side, L, Walker, L, Morrison, P, Donaldson, A, Kennedy, J, Foo, C, Godwin, A K, Schmutzler, R K, Wappenschmidt, B, Rhiem, K, Engel, C, Meindl, A, Ditsch, N, Arnold, N, Plendl, H J, Niederacher, D, Sutter, C, Wang-Gohrke, S, Steinemann, D, Preisler-Adams, S, Kast, K, Varon-Mateeva, R, Gehrig, A, Stoppa-Lyonnet, D, Sinilnikova, O M, Mazoyer, S, Damiola, F, Poppe, B, Claes, K, Piedmonte, M, Tucker, K, Backes, F, Rodríguez, G, Brewster, W, Wakeley, K, Rutherford, T, Caldés, T, Nevanlinna, H, Aittomäki, K, Rookus, M A, van Os, T A M, van der Kolk, L, de Lange, J L, Meijers-Heijboer, H E J, van der Hout, A H, van Asperen, C J, Gómez Garcia, E B, Hoogerbrugge, N, Collée, J M, van Deurzen, C H M, van der Luijt, R B, Devilee, P, Hebon, Olah, E, Lázaro, C, Teulé, A, Menéndez, M, Jakubowska, A, Cybulski, C, Gronwald, J, Lubinski, J, Durda, K, Jaworska-Bieniek, K, Johannsson, O T, Maugard, C, Montagna, M, Tognazzo, S, Teixeira, M R, Healey, S, Investigators, K, Olswold, C, Guidugli, L, Lindor, N, Slager, S, Szabo, C I, Vijai, J, Robson, M, Kauff, N, Zhang, L, Rau-Murthy, R, Fink-Retter, A, Singer, C F, Rappaport, C, Geschwantler Kaulich, D, Pfeiler, G, Tea, M-K, Berger, A, Phelan, C M, Greene, M H, Mai, P L, Lejbkowicz, F, Andrulis, I, Mulligan, A M, Glendon, G, Toland, A E, Bojesen, A, Pedersen, I S, Sunde, L, Thomassen, M, Kruse, T A, Jensen, U B, Friedman, E, Laitman, Y, Shimon, S P, Simard, J, Easton, D F, Offit, K, Couch, F J, Chenevix-Trench, G, Antoniou, A C & Benitez, J 2014, ' DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers ', P L o S Genetics, vol. 10, no. 4, pp. e1004256 . https://doi.org/10.1371/journal.pgen.1004256, PLoS genetics, 10(4). Public Library of Science, PLoS Genetics; Vol 10, Plos Genetics, 10, e1004256, PLoS Genetics, 10(4), PLoS Genetics, Vol 10, Iss 4, p e1004256 (2014), Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, PLoS genetics, 10(4):e1004256. PUBLIC LIBRARY SCIENCE, PLoS Genetics, 10(4):e1004256. Public Library of Science, Plos Genetics, 10, 4, pp. e1004256, PLOS GENETICS
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