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Impact of Pubertal Maturation and Chronologic Age on Sex Steroids in Peripubertal Girls
- Source :
- The Journal of Clinical Endocrinology & Metabolism. 104:2971-2977
- Publication Year :
- 2019
- Publisher :
- The Endocrine Society, 2019.
-
Abstract
- CONTEXT: There is a 4- to 5-year variation in age of breast maturation in girls. OBJECTIVE: To examine longitudinal changes in sex hormone values relative to chronologic age and time relative to breast maturation. SETTING AND DESIGN: Longitudinal observational study into which girls were recruited at 6 to 7 years of age and followed up every 6 months. MAIN OUTCOME MEASURES: Maturation status, chronologic age, race, and fasting blood specimen data were obtained. Hormones were analyzed at 6-month intervals between 2 years before and 1 year after breast maturation, using HPLC tandem mass spectroscopy. RESULTS: Estradiol and estrone levels correlated with chronologic age (R = 0.350 and 0.444, respectively); time was correlated relative to breast maturation (R = 0.222 and 0.323, respectively; all correlations, P < 0.0001). In generalized estimating equation (GEE) models, chronologic age and time relative to pubertal onset were significantly associated with serum estradiol, with similar results for estrone. Local estimated scatterplot smoothing for estradiol and estrone, by chronologic age, demonstrated differences between black and white girls, especially between 8.5 and 11 years of age, but not by race in time relative to breast maturation. Testosterone level was correlated to chronologic age (R = 0.362) and time relative to breast maturation (R = 0.259); in the GEE model, only chronologic age was significant. CONCLUSION: Chronologic age as well as time relative to onset of puberty provided unique information regarding estradiol and estrone concentrations in peripubertal girls. Serum estrogen concentrations should be evaluated with reference to chronologic age and race.
- Subjects :
- medicine.medical_specialty
Estrone
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Context (language use)
Biochemistry
White People
Gee
Serum estrogen
chemistry.chemical_compound
Endocrinology
Sex hormone-binding globulin
Tandem Mass Spectrometry
Internal medicine
medicine
Humans
Testosterone
Breast
Longitudinal Studies
Sexual Maturation
Child
Generalized estimating equation
Clinical Research Articles
Chromatography, High Pressure Liquid
Estradiol
biology
Dehydroepiandrosterone Sulfate
business.industry
Puberty
Biochemistry (medical)
Age Factors
Hispanic or Latino
Black or African American
chemistry
biology.protein
Female
business
Hormone
Puberty onset
Subjects
Details
- ISSN :
- 19457197 and 0021972X
- Volume :
- 104
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Endocrinology & Metabolism
- Accession number :
- edsair.doi.dedup.....97ed9a31d90ee369d18b051074ea43e8