Back to Search
Start Over
Polymorphisms of the Factor VII Gene Associated with the Low Activities of Vitamin K-Dependent Coagulation Factors in One-Month-Old Infants
- Source :
- The Tohoku Journal of Experimental Medicine. 211:1-8
- Publication Year :
- 2007
- Publisher :
- Tohoku University Medical Press, 2007.
-
Abstract
- Despite administration of vitamin K (VK), some infants show lower activity of VK-dependent coagulation factors and they could develop intracranial hemorrhage. For preventing VK deficiency bleeding (VKDB) in infants, oral administration of VK and a screening test for VK deficiency are carried out in Japan. For the screening, the total activity of VK-dependent coagulation factors is measured using a commercial product, Normotest. This study was undertaken to clarify the importance of the following genetic and environmental factors on the coagulation status in one-month-old infants: two polymorphisms in the factor VII gene, -323P0/10 (a 10-bp insertion in the promoter region at position -323) and R353Q (the replacement of arginine [R] with glutamine [Q] at residue 353) and sex, age, gestational age, birth weight, and feeding regimen. Two hundred Japanese infants (34.6 +/- 4.0 days old) were screened for VK-dependent coagulation activity with Normotest and were genotyped for the two polymorphisms. Among the subjects screened, 18 infants (9%) carried the P10 allele and 26 (13%) carried the R353Q allele. Multiple regression analysis showed that the 10-bp inserted (P10) allele or the Q allele was associated with the lower coagulation activities. The coagulation activities for the R/Q genotype were significantly lower than those for the R/R genotype and those for the P0/P10 genotype were significantly lower than those for the P0/P0 genotype. Therefore, infants who carry the P10 allele or the Q allele show lower activity of VK-dependent coagulation factors. These infants may have a higher risk of VKDB manifestation.
- Subjects :
- Male
medicine.medical_specialty
Vitamin K
Genotype
Birth weight
Gestational Age
Biology
Gastroenterology
General Biochemistry, Genetics and Molecular Biology
chemistry.chemical_compound
Sex Factors
Gene Frequency
Oral administration
Internal medicine
medicine
Birth Weight
Humans
Allele
Blood Coagulation
Genetics
Polymorphism, Genetic
Factor VII
Body Weight
Infant, Newborn
Infant
Gestational age
General Medicine
Vitamin K Deficiency Bleeding
Blood Coagulation Factors
Bottle Feeding
Glutamine
Breast Feeding
chemistry
Coagulation
Regression Analysis
Female
Vitamin K Deficiency
Blood Coagulation Tests
Subjects
Details
- ISSN :
- 13493329 and 00408727
- Volume :
- 211
- Database :
- OpenAIRE
- Journal :
- The Tohoku Journal of Experimental Medicine
- Accession number :
- edsair.doi.dedup.....97e976fb721d711855cac840b9b85259