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Impact of IgA isoforms on their ability to activate dendritic cells and to prime T cells
- Source :
- European Journal of Immunology, European Journal of Immunology, Wiley-VCH Verlag, 2020, 50 (9), pp.1295-1306. ⟨10.1002/eji.201948177⟩, European Journal of Immunology, 2020, 50 (9), pp.1295-1306. ⟨10.1002/eji.201948177⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- Human IgA could be from different isotypes (IgA1/IgA2) and/or isoforms (monomeric, dimeric, or secretory). Monomeric IgA mainly IgA1 are considered as an anti-inflammatory isotype whereas dimeric/secretory IgA have clearly dual pro- and anti-inflammatory effects. Here, we show that IgA isotypes and isoforms display different binding abilities to FcαRI, Dectin-1, DC-SIGN, and CD71 on monocyte-derived dendritic cells (moDC). We describe that IgA regulate the expression of their own receptors and trigger modulation of moDC maturation. We also demonstrate that dimeric IgA2 and IgA1 induce different inflammatory responses leading to cytotoxic CD8+ T cells activation. moDC stimulation by dimeric IgA2 was followed by a strong pro-inflammatory effect. Our study highlights differences regarding IgA isotypes and isoforms in the context of DC conditioning. Further investigations are needed on the activation of adaptive immunity by IgA in the context of microbiota/IgA complexes during antibody-mediated immune selection.
- Subjects :
- 0301 basic medicine
Gene isoform
secretory
[SDV]Life Sciences [q-bio]
isotype
Immunology
Transferrin receptor
Context (language use)
Biology
CD8-Positive T-Lymphocytes
Lymphocyte Activation
NO
03 medical and health sciences
fluids and secretions
0302 clinical medicine
stomatognathic system
Immunology and Allergy
Cytotoxic T cell
Humans
Protein Isoforms
Receptor
ComputingMilieux_MISCELLANEOUS
isoform
Dendritic Cells
Acquired immune system
dendritic cells, IgA, isoform, isotype, secretory
Isotype
Cell biology
Immunoglobulin A
[SDV] Life Sciences [q-bio]
030104 developmental biology
IgA
CD8
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 00142980 and 15214141
- Database :
- OpenAIRE
- Journal :
- European Journal of Immunology, European Journal of Immunology, Wiley-VCH Verlag, 2020, 50 (9), pp.1295-1306. ⟨10.1002/eji.201948177⟩, European Journal of Immunology, 2020, 50 (9), pp.1295-1306. ⟨10.1002/eji.201948177⟩
- Accession number :
- edsair.doi.dedup.....97d9bcaedafc111cff4e1d76ed067c0f