Back to Search
Start Over
Serum and synovial fluid concentrations of cold-inducible RNA-binding protein in patients with rheumatoid arthritis
- Source :
- International Journal of Rheumatic Diseases. 21:148-154
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Aim There is growing evidence that cold-inducible RNA-binding protein (CIRP) promotes inflammatory responses. This study investigated the relationship between CIRP and rheumatoid arthritis (RA). Methods Peripheral blood and synovial fluid were collected from 15 patients with RA and from 16 patients with osteoarthritis (OA). The concentration of CIRP was measured with the sandwich enzyme-linked immunosorbent assay (ELISA). Results The concentration of serum CIRP was significantly elevated in the RA patient group (RA patients = 26.39 ± 10.48 pg/mL, OA patients = 17.14 ± 7.24 pg/mL, P = 0.009). Furthermore, the RA patient group had a significantly higher CIRP concentration than that of the OA patient group in synovial fluid (153.56 ± 108.93 pg/mL vs. 23.63 ± 16.18 pg/mL, P < 0.001). The mean synovial fluid concentration of CIRP was significantly higher than that of the serum concentration in the RA patient group (serum concentration = 26.39 ± 10.48 pg/mL, synovial fluid = 153.56 ± 108.93 pg/mL, P < 0.001). Disease Activity Score of 28 joints (DAS28)-ESR (erythrocyte sedimentation rate) and DAS28-CRP (C-reactive protein) were positively correlated with the synovial fluid concentration of CIRP (DAS28-ESR: r = 0.582, P = 0.023; DAS28-CRP: r = 0.541, P = 0.037). Conclusion The serum and synovial concentrations of CIRP in the RA patients were increased compared to the OA patients. Additionally, the synovial concentration of CIRP in RA patients correlated well with disease activity, that is, the DAS28-ESR/CRP. Based on these results, CIRP mediates inflammation and is a potential marker for synovial inflammation.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Enzyme-Linked Immunosorbent Assay
Inflammation
Blood Sedimentation
Osteoarthritis
Severity of Illness Index
Arthritis, Rheumatoid
Disability Evaluation
03 medical and health sciences
Rheumatology
Downregulation and upregulation
Internal medicine
Synovial Fluid
medicine
Humans
Synovial fluid
Aged
medicine.diagnostic_test
biology
business.industry
C-reactive protein
RNA-Binding Proteins
Middle Aged
Cold inducible RNA binding protein
medicine.disease
Up-Regulation
C-Reactive Protein
030104 developmental biology
Endocrinology
Rheumatoid arthritis
Erythrocyte sedimentation rate
Immunology
biology.protein
Female
Inflammation Mediators
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 17561841
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- International Journal of Rheumatic Diseases
- Accession number :
- edsair.doi.dedup.....97cf98a895218c9a8f99b236833d8f54