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T-bet+ B cells are induced by human viral infections and dominate the HIV gp140 response
- Source :
- JCI insight, vol 2, iss 8
- Publication Year :
- 2017
- Publisher :
- eScholarship, University of California, 2017.
-
Abstract
- Humoral immunity is critical for viral control, but the identity and mechanisms regulating human antiviral B cells are unclear. Here, we characterized human B cells expressing T-bet and analyzed their dynamics during viral infections. T-bet+ B cells demonstrated an activated phenotype, a distinct transcriptional profile, and were enriched for expression of the antiviral immunoglobulin isotypes IgG1 and IgG3. T-bet+ B cells expanded following yellow fever virus and vaccinia virus vaccinations and also during early acute HIV infection. Viremic HIV-infected individuals maintained a large T-bet+ B cell population during chronic infection that was associated with increased serum and cell-associated IgG1 and IgG3 expression. The HIV gp140-specific B cell response was dominated by T-bet-expressing memory B cells, and we observed a concomitant biasing of gp140-specific serum immunoglobulin to the IgG1 isotype. These findings suggest that T-bet induction promotes antiviral immunoglobulin isotype switching and development of a distinct T-bet+ B cell subset that is maintained by viremia and coordinates the HIV Env-specific humoral response.
- Subjects :
- 0301 basic medicine
Population
Immunology
chemical and pharmacologic phenomena
Viremia
Biology
Virus
AIDS/HIV
Vaccine Related
03 medical and health sciences
0302 clinical medicine
medicine
2.2 Factors relating to the physical environment
2.1 Biological and endogenous factors
Aetiology
education
Vaccine Related (AIDS)
B cell
education.field_of_study
Prevention
hemic and immune systems
General Medicine
medicine.disease
Virology
Isotype
030104 developmental biology
medicine.anatomical_structure
Infectious Diseases
Good Health and Well Being
Immunoglobulin class switching
Humoral immunity
biology.protein
HIV/AIDS
Immunization
Antibody
Infection
Research Article
030215 immunology
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- JCI insight, vol 2, iss 8
- Accession number :
- edsair.doi.dedup.....97b7926d1ad9952cc4ced88c82da3ed5