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Overview of health-related quality of life and toxicity of non-small cell lung cancer patients receiving curative-intent radiotherapy in a real-life setting (the REQUITE study)
- Source :
- Lung Cancer, Lung Cancer, 166, 228-241. Elsevier Ireland Ltd, LUNG CANCER
- Publication Year :
- 2021
-
Abstract
- OBJECTIVES: Radiotherapy-induced toxicity may negatively impact health-related quality of life (HRQoL). This report investigates the impact of curative-intent radiotherapy on HRQoL and toxicity in early stage and locally-advanced non-small cell lung cancer patients treated with radiotherapy or chemo-radiotherapy enrolled in the observational prospective REQUITE study.MATERIALS AND METHODS: HRQoL was assessed using the European Organisation for Research and Treatment of Cancer QLQ-C30 questionnaire up to 2 years post radiotherapy. Eleven toxicities were scored by clinicians using the Common Terminology Criteria for Adverse Events (CTCAE) version 4. Toxicity scores were calculated by subtracting baseline values. Mixed model analyses were applied to determine statistical significance (p ≤ 0.01). Meaningful clinical important differences (MCID) were determined for changes in HRQoL. Analysis was performed on the overall data, different radiotherapy techniques, multimodality treatments and disease stages.RESULTS: Data of 510 patients were analysed. There was no significant change in HRQoL or its domains, except for deterioration in cognitive functioning (p = 0.01). Radiotherapy technique had no significant impact on HRQoL. The addition of chemotherapy was significantly associated with HRQoL over time (p CONCLUSIONS: While overall HRQoL and toxicity did not change over time, some patients improved, whereas others experienced acute radiotherapy-induced toxicities and deteriorated HRQoL, especially physical and cognitive functioning. Patient characteristics, more so than radiotherapy technique and treatment modality, impact post-radiotherapy toxicity and HRQoL outcomes. This stresses the importance of considering the potential impact of radiotherapy on individuals' HRQoL, symptoms and toxicity in treatment decision-making.
- Subjects :
- Pulmonary and Respiratory Medicine
Cancer Research
Lung Neoplasms
IMPACT
QLQ-C30
CONCURRENT CHEMOTHERAPY
EORTC QLQ-LC13
RADIATION-THERAPY IMRT
Article
TRIALS
Oncology
CLINICAL-PRACTICE
Carcinoma, Non-Small-Cell Lung
Surveys and Questionnaires
END-POINTS
Medicine and Health Sciences
SURVIVAL
Quality of Life
DOSE-ESCALATION
Humans
Prospective Studies
REPORTED OUTCOME MEASURES
Radiation Injuries
CLINICAL-TRIALS
Subjects
Details
- ISSN :
- 18728332 and 01695002
- Volume :
- 166
- Database :
- OpenAIRE
- Journal :
- Lung cancer (Amsterdam, Netherlands)
- Accession number :
- edsair.doi.dedup.....97af68ea6845db184efcd37d4e7f92d1